Anticorps Polyclonal de lapin anti-ERLIN2

ERLIN2 Polyclonal Antibody for WB, IHC, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, rat, souris

Applications

WB, IHC, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 14781-1-PBS

Synonymes

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Galerie de données de validation

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  WB analysis of HeLa using 14781-1-AP (same clone as 14781-1-PBS)

  HeLa cells were subjected to SDS PAGE followed by western blot with 14781-1-AP (ERLIN2 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 14781-1-PBS in a different storage buffer formulation.

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  WB analysis of HeLa using 14781-1-AP (same clone as 14781-1-PBS)

  HeLa cells were subjected to SDS PAGE followed by western blot with 14781-1-AP (ERLIN2 antibody) at dilution of 1:100 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 14781-1-PBS in a different storage buffer formulation.

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  IHC staining of human liver cancer using 14781-1-AP (same clone as 14781-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human liver cancer tissue slide using 14781-1-AP (ERLIN2 Antibody) at dilution of 1:200 (under 40x lens). This data was developed using the same antibody clone with 14781-1-PBS in a different storage buffer formulation.

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  IHC staining of human liver cancer using 14781-1-AP (same clone as 14781-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human liver cancer tissue slide using 14781-1-AP (ERLIN2 Antibody) at dilution of 1:200 (under 10x lens). This data was developed using the same antibody clone with 14781-1-PBS in a different storage buffer formulation.

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Informations sur le produit

14781-1-PBS cible ERLIN2 dans les applications de WB, IHC, Indirect ELISA et montre une réactivité avec des échantillons Humain, rat, souris

• Réactivité: Humain, rat, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: ERLIN2 Protéine recombinante Ag6369
• Nom complet: ER lipid raft associated 2
• Masse moléculaire calculée: 38 kDa
• Poids moléculaire observé: 38-45 kDa
• Numéro d’acquisition GenBank: BC067765
• Symbole du gène: ERLIN2
• Identification du gène (NCBI): 11160
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

ERLIN2, also named as C8orf2 and SPFH2, is a component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs) such as ITPR1 (PubMed:19240031, PubMed:17502376). It promotes sterol-accelerated ERAD of HMGCR probably implicating an AMFR/gp78-containing ubiquitin ligase complex (PubMed:21343306). ERLIN2 is involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. The MW of ERLIN1/ERLIN2 complex is about 70 kDa.

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