Anticorps Polyclonal de lapin anti-ESCO2

ESCO2 Polyclonal Antibody for WB, IHC, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, rat, souris

Applications

WB, IHC, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 23525-1-PBS

Synonymes

N acetyltransferase ESCO2, hEFO2, Establishment factor-like protein 2, EFO2p, EFO2

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Galerie de données de validation

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  WB analysis using 23525-1-AP (same clone as 23525-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 23525-1-AP (ESCO2 antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 23525-1-PBS in a different storage buffer formulation.

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  WB analysis using 23525-1-AP (same clone as 23525-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 23525-1-AP (ESCO2 antibody) at dilution of 1:1500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 23525-1-PBS in a different storage buffer formulation.

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  IHC staining of human skin cancer using 23525-1-AP (same clone as 23525-1-PBS)

  Immunohistochemical analysis of paraffin-embedded skin cancer slide using 23525-1-AP (ESCO2 antibody) at dilution of 1:300 (under 20x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 23525-1-PBS in a different storage buffer formulation.

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Informations sur le produit

23525-1-PBS cible ESCO2 dans les applications de WB, IHC, Indirect ELISA et montre une réactivité avec des échantillons Humain, rat, souris

• Réactivité: Humain, rat, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: ESCO2 Protéine recombinante Ag18893
• Nom complet: establishment of cohesion 1 homolog 2 (S. cerevisiae)
• Masse moléculaire calculée: 601 aa, 68 kDa
• Poids moléculaire observé: 65-70 kDa
• Numéro d’acquisition GenBank: BC146562
• Symbole du gène: ESCO2
• Identification du gène (NCBI): 157570
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purifié par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

ESCO2 is also known as Establishment of Sister Chromatid Cohesion N-Acetyltransferase 2, EFO2. This gene encodes a member of the family of acetyltransferases involved in the establishment of sister chromatid cohesion during S phase and postreplicative sister chromatid cohesion induced by double-strand breaks (PubMed: 15821733). Mutations in the ESCO2 gene are associated with a rare genetic disorder called Roberts syndrome or SC phocomelia syndrome (PubMed: 16380922). The loss of function or impaired activity of the ESCO2 protein due to mutations disrupts the proper cohesion of sister chromatids, leading to chromosomal abnormalities and the characteristic features of Roberts syndrome. ESCO2 can be detected as about 65-70 kDa.

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