Anticorps Recombinant de lapin anti-ESM1

ESM1 Recombinant Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, rat, souris

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

250287H3

N° de cat : 86027-1-PBS

Synonymes

endocan, endothelial cell molecule 1, Endothelial cell specific molecule 1, Endothelial cell-specific molecule 1, ESM-1

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Galerie de données de validation

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  WB analysis using 86027-1-RR (same clone as 86027-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 86027-1-RR (ESM1 antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 86027-1-PBS in a different storage buffer formulation.

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  Affinity and Kinetic Characterization of 86027-1-RR

  Biolayer interferometry (BLl) kinetic assays of 86027-1-RR against Human ESM1 were performed. The affinity constant is 66.5 nM.

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Informations sur le produit

86027-1-PBS cible ESM1 dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain, rat, souris

• Réactivité: Humain, rat, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: ESM1 Protéine recombinante Ag3019
• Nom complet: endothelial cell-specific molecule 1
• Masse moléculaire calculée: 184 aa, 20 kDa
• Poids moléculaire observé: 14 kDa
• Numéro d’acquisition GenBank: BC011989
• Symbole du gène: ESM1
• Identification du gène (NCBI): 11082
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

ESM1, also known as endocan or endothelial cell-specific molecule 1, is a protein-coding gene that encodes a secreted proteoglycan primarily expressed in endothelial cells of human tissues, including lung, kidney, and vascular systems. The protein consists of a 20 kDa core protein with a dermatan sulfate chain, forming a 50 kDa mature proteoglycan. ESM1 plays a crucial role in endothelial cell proliferation, migration, and angiogenesis (blood vessel formation). It modulates vascular development and maintains endothelial homeostasis. Overexpression of ESM1 is observed in cancers such as gastric, cervical, and lung tumors, where it promotes angiogenesis and tumor progression via pathways like VEGF/ERK signaling. Elevated serum ESM1 levels are associated with poor clinical outcomes in cancer patients.

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