Anticorps Recombinant de lapin anti-EXD2

EXD2 Recombinant Antibody for WB, ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, rat, souris

Applications

WB, ELISA

Conjugaison

Non conjugué

CloneNo.

250133E4

N° de cat : 85832-4-RR

Synonymes

3'-5' exoribonuclease EXD2, C14orf114, EC:3.1.11.1, EC:3.1.13.-, EXDL2

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Galerie de données de validation

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  WB analysis using 85832-4-RR

  Various lysates were subjected to SDS PAGE followed by western blot with 85832-4-RR (EXD2 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours.

• 

  WB analysis using 85832-4-RR

  Various lysates were subjected to SDS PAGE followed by western blot with 85832-4-RR (EXD2 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours.

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Applications testées

• Résultats positifs en WB: tissu pulmonaire de souris, cellules A431, tissu cérébral humain fœtal, tissu pancréatique de souris

Dilution recommandée

• Western Blot (WB): WB : 1:5000-1:50000

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, check data in validation data gallery

Informations sur le produit

85832-4-RR cible EXD2 dans les applications de WB, ELISA et montre une réactivité avec des échantillons Humain, rat, souris

• Réactivité: Humain, rat, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: EXD2 Protéine recombinante Ag14090
• Nom complet: exonuclease 3'-5' domain containing 2
• Masse moléculaire calculée: 70 kD aa, 56 kDa
• Poids moléculaire observé: 56 kDa, 70 kDa
• Numéro d’acquisition GenBank: BC001962
• Symbole du gène: EXD2
• Identification du gène (NCBI): 55218
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS with 0.02% sodium azide and 50% glycerol
• Conditions de stockage: Stocker à -20°C. Stable pendant un an après l'expédition. L'aliquotage n'est pas nécessaire pour le stockage à -20^oC Les 20ul contiennent 0,1% de BSA.

Informations générales

EXD2 (Exonuclease 3'-5' Domain Containing 2), is a protein with exonuclease activity of 3'-5' nucleic acid, which is involved in many biological processes in cells, including DNA repair, RNA processing and mitochondrial translation. EXD2 protein is mainly located in mitochondrial outer membrane, intermediate fiber cytoskeleton and DNA damage site. This protein may be a potential drug target in some cancers. For example, in ALT (telomere selective elongation) dependent cancer, the co-elimination of EXD2 with BLM, DNA2 or POLD3 may mediate synthetic lethality. In addition, EXD2 inhibitors may exert anticancer effects by inhibiting mitochondrial translation and metabolic reprogramming. It has two isoforms with molecular weights of 56 kDa and 70 kDa respectively.

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