Anticorps Polyclonal de lapin anti-EXO1/Exonuclease 1

• Phare
• Validé par KD/KO

EXO1/Exonuclease 1 Polyclonal Antibody for WB, IP, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, souris

Applications

WB, IP, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 16253-1-PBS

Synonymes

EXO1, EC:3.1.-.-, EXOI, Exonuclease 1, Exonuclease I

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Galerie de données de validation

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  WB analysis using 16253-1-AP (same clone as 16253-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 16253-1-AP (EXO1 antibody) at dilution of 1:8000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 16253-1-PBS in a different storage buffer formulation.

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  WB analysis of Jurkat using 16253-1-AP (same clone as 16253-1-PBS)

  Jurkat cells were subjected to SDS PAGE followed by western blot with 16253-1-AP (EXO1 antibody) at dilution of 1:800 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 16253-1-PBS in a different storage buffer formulation.

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  IP experiment of mouse thymus using 16253-1-AP (same clone as 16253-1-PBS)

  IP result of anti-EXO1 (IP:16253-1-AP, 4ug; Detection:16253-1-AP 1:500) with mouse thymus tissue lysate 2800ug. This data was developed using the same antibody clone with 16253-1-PBS in a different storage buffer formulation.

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Informations sur le produit

16253-1-PBS cible EXO1/Exonuclease 1 dans les applications de WB, IP, Indirect ELISA et montre une réactivité avec des échantillons Humain, souris

• Réactivité: Humain, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: EXO1/Exonuclease 1 Protéine recombinante Ag9253
• Nom complet: exonuclease 1
• Masse moléculaire calculée: 94 kDa
• Poids moléculaire observé: 115-120 kDa
• Numéro d’acquisition GenBank: BC007491
• Symbole du gène: EXO1
• Identification du gène (NCBI): 9156
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

EXO1, also named as HEX1, is a 846 amino acid protein, which belongs to the XPG/RAD2 endonuclease family. EXO1 subfamily. EXO1 is highly expressed in bone marrow, testis and thymus and at lower levels in colon, lymph nodes, ovary, placenta, prostate, small intestine, spleen and stomach. EXO1 as 5'->3' double-stranded DNA exonuclease, which may also possess a cryptic 3'->5' double-stranded DNA exonuclease activity. EXO1 functions in DNA mismatch repair (MMR) to excise mismatch-containing DNA tracts directed by strand breaks located either 5' or 3' to the mismatch. The calculated molecular weight of EXO1 is 94 kDa, but the modified EXO1 protein is about 115 kDa.

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