Anticorps Polyclonal de lapin anti-EXTL3

EXTL3 Polyclonal Antibody for IP, ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, souris

Applications

IP, ELISA

Conjugaison

Non conjugué

N° de cat : 10588-1-PBS

Synonymes

EC:2.4.1.223, Exostosin-like 3, EXTL1L, EXTR1, EXT-related protein 1

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Galerie de données de validation

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  IP experiment of mouse pancreas using 10588-1-AP (same clone as 10588-1-PBS)

  IP result of anti-EXTL3 (IP:10588-1-AP, 4ug; Detection:10588-1-AP 1:1000) with mouse pancreas tissue lysate 3200 ug. This data was developed using the same antibody clone with 10588-1-PBS in a different storage buffer formulation.

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  IP experiment of HEK-293T using 10588-1-AP (same clone as 10588-1-PBS)

  IP result of anti-EXTL3 (IP:10588-1-AP, 4ug; Detection:10588-1-AP 1:1000) with HEK-293T cells lysate 1840 ug. This data was developed using the same antibody clone with 10588-1-PBS in a different storage buffer formulation.

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Informations sur le produit

10588-1-PBS cible EXTL3 dans les applications de IP, ELISA et montre une réactivité avec des échantillons Humain, souris

• Réactivité: Humain, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: EXTL3 Protéine recombinante Ag0936
• Nom complet: exostoses (multiple)-like 3
• Masse moléculaire calculée: 105 kDa
• Poids moléculaire observé: 105 kDa
• Numéro d’acquisition GenBank: BC006363
• Symbole du gène: EXTL3
• Identification du gène (NCBI): 2137
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

Exostosin like glycosyltransferase 3 (EXTL3), also known as RPR, is located at chromosome 8p21.1 and composed of 919 amino acids, making it the longest member of the EXT family (PMID: 35676258). EXTL3 encodes the glycosyltransferases responsible for the biosynthesis of the backbone structure of heparan sulfate (HS) (PMID: 24128412). EXTL3 has been identified as a receptor molecule for regenerating islet-derived (REG) protein ligands, which have been shown to stimulate islet β-cell growth. Mutations in EXTL3 could lead to skeletal dysplasia, developmental delay, and severe immune deficiency (PMID: 28148688). The predicted molecular weight is 105 kDa, but we detected the band at 65 kDa perhaps due to alternative splicing (PMID: 14618397).

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