Anticorps Recombinant de lapin anti-Endoglin/CD105

Endoglin/CD105 Recombinant Antibody for FC

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

FC

Conjugaison

Non conjugué

CloneNo.

230047E5

N° de cat : 98013-1-RR

Synonymes

CD105, 230047E5, HHT1, ENG, Endoglin

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Galerie de données de validation

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  FC experiment of human PBMCs using 98013-1-RR

  1x10^6 human PBMCs were surface stained with 0.25 ug Anti-Human Endoglin/CD105 Rabbit Recombinant Antibody (98013-1-RR, Clone:230047E5) and PE-conjugated Goat Anti-Rabbit IgG(red), or 0.25 ug Isotype Control (blue). Cells were not fixed. Monocytes were gated.

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  Affinity and Kinetic Characterization of 98013-1-RR

  Biolayer interferometry (BLl) kinetic assays of 98013-1-RR against Human Endoglin/CD105 were performed. The affinity constant is 6.83 nM.

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Applications testées

• Résultats positifs en cytométrie: CMSP humaines,

Dilution recommandée

Application	Dilution
This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, check data in validation data gallery

Informations sur le produit

98013-1-RR cible Endoglin/CD105 dans les applications de FC et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: Protéine recombinante
• Nom complet: endoglin
• Masse moléculaire calculée: 71 kDa
• Numéro d’acquisition GenBank: BC014271
• Symbole du gène: CD105
• Identification du gène (NCBI): 2022
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS with 0.09% sodium azide
• Conditions de stockage: Store at 2-8°C. Stable for one year after shipment.

Informations générales

Endoglin (ENG, CD105) is a homodimeric cell membrane glycoprotein of 180 kDa, composed of disulphide-linked subunits of 90-95 kDa. Endoglin is a proliferation-associated and hypoxia-inducible protein mainly expressed on vascular endothelial cells. It acts as an accessory receptor for transforming growth factor beta (TFG-β) and is involved in vascular development and remodeling. The important role of Endoglin in angiogenesis and in tumor progression makes it an ideal target for antiangiogenic therapy and a good marker for tumor prognosis. (PMID: 1326540; 14528280; 21737653; 12773481)

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