Anticorps Recombinant de lapin anti-F2RL3

F2RL3 Recombinant Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, rat, souris

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

250132A3

N° de cat : 86509-1-PBS

Synonymes

Coagulation factor II receptor-like 3, PAR 4, PAR4, PAR-4, Proteinase activated receptor 4

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Galerie de données de validation

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  WB analysis using 86509-1-RR (same clone as 86509-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 86509-1-RR (F2RL3 antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 86509-1-PBS in a different storage buffer formulation.

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  Affinity and Kinetic Characterization of 86509-1-RR

  Biolayer interferometry (BLl) kinetic assays of 86509-1-RR against Human F2RL3 were performed. The affinity constant is 22.3 nM.

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Informations sur le produit

86509-1-PBS cible F2RL3 dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain, rat, souris

• Réactivité: Humain, rat, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: F2RL3 Protéine recombinante Ag13624
• Nom complet: coagulation factor II (thrombin) receptor-like 3
• Masse moléculaire calculée: 385 aa, 41 kDa
• Poids moléculaire observé: 45 kDa
• Numéro d’acquisition GenBank: BC074782
• Symbole du gène: F2RL3
• Identification du gène (NCBI): 9002
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

Coagulation factor II receptor-like 3 (F2RL3) encodes a member of the protease-activated receptor subfamily, also known as protease-activated receptor 4 (PAR4), which takes partin platelet activation, intimal hyperplasia and inflammation (PMID:34284820). An absence of PAR4 in mouse models results in impaired hemostasis and a protection against pulmonary embolism, and a small number of missense coding variants in F2RL3 that alter platelet aggregation and function have been described(PMID:35012325).

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