Anticorps Polyclonal de lapin anti-FANCD2

• Phare
• Validé par KD/KO

FANCD2 Polyclonal Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 28619-1-PBS

Synonymes

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Galerie de données de validation

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  WB analysis using 28619-1-AP (same clone as 28619-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 28619-1-AP (FANCD2 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 28619-1-PBS in a different storage buffer formulation.

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Informations sur le produit

28619-1-PBS cible FANCD2 dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: FANCD2 Protéine recombinante Ag29460
• Nom complet: Fanconi anemia, complementation group D2
• Masse moléculaire calculée: 164 kDa
• Poids moléculaire observé: 150 kDa
• Numéro d’acquisition GenBank: NM_001018115
• Symbole du gène: FANCD2
• Identification du gène (NCBI): 2177
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

FANCD2, also named as FACD and FACD2, is required for maintenance of chromosomal stability. FANCD2 promotes accurate and efficient pairing of homologs during meiosis. FANCD2 is involved in the repair of DNA double-strand breaks, both by homologous recombination and single-strand annealing. It may participate in S phase and G2 phase checkpoint activation upon DNA damage. It promotes BRCA2/FANCD1 loading onto damaged chromatin. FANCD2 may also be involved in B-cell immunoglobulin isotype switching. Defects in FANCD2 are a cause of Fanconi anemia (FA) which is a genetically heterogeneous, autosomal recessive disorder characterized by progressive pancytopenia, a diverse assortment of congenital malformations, and a predisposition to the development of malignancies.

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