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Anticorps Polyclonal de lapin anti-FANCM

FANCM Polyclonal Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, rat, souris

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 12954-1-PBS

Synonymes

Galerie de données de validation

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  • Western Blot (WB) analysis of HeLa cells using FANCM Polyclonal antibody (12954-1-AP)

    WB analysis of HeLa using 12954-1-AP (same clone as 12954-1-PBS)

    HeLa cells were subjected to SDS PAGE followed by western blot with 12954-1-AP (FANCM antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 12954-1-PBS in a different storage buffer formulation.

Informations sur le produit

12954-1-PBS cible FANCM dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain, rat, souris

Réactivité Humain, rat, souris
Hôte / Isotype Lapin / IgG
Clonalité Polyclonal
Type Anticorps
Immunogène FANCM Protéine recombinante Ag3618
Nom complet Fanconi anemia, complementation group M
Masse moléculaire calculée 2048 aa, 232 kDa
Poids moléculaire observé 250 kDa, 232 kDa
Numéro d’acquisition GenBankBC036056
Symbole du gène FANCM
Identification du gène (NCBI) 57697
Conjugaison Non conjugué
Forme Liquide
Méthode de purification Purification par affinité contre l'antigène
Tampon de stockage PBS only
Conditions de stockageStore at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

FANCM (Fanconi anemia group M protein) is a DNA-dependent ATPase component of the Fanconi anemia (FA) core complex (PMID: 16116422). It is required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage (PMID:16116422; 19423727; 20347428). FANCM is localized in the cell nucleus and can bind double-stranded DNA (dsDNA), fork-structured DNA (fsDNA), and Holliday junction substrates (PMID: 20347428; 20347429).

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