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Anticorps Polyclonal de lapin anti-FAT2

FAT2 Polyclonal Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 31490-1-PBS

Synonymes

Galerie de données de validation

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  • Western Blot (WB) analysis of various lysates using FAT2 Polyclonal antibody (31490-1-AP)

    WB analysis using 31490-1-AP (same clone as 31490-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 31490-1-AP (FAT2 antibody) at dilution of 1:600 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 31490-1-PBS in a different storage buffer formulation.

Informations sur le produit

31490-1-PBS cible FAT2 dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain

Réactivité Humain
Hôte / Isotype Lapin / IgG
Clonalité Polyclonal
Type Anticorps
Immunogène FAT2 Protéine recombinante Ag34942
Nom complet FAT tumor suppressor homolog 2 (Drosophila)
Masse moléculaire calculée479 kDa
Poids moléculaire observé500-600 kDa
Numéro d’acquisition GenBankNM_001447
Symbole du gène FAT2
Identification du gène (NCBI) 2196
Conjugaison Non conjugué
Forme Liquide
Méthode de purification Purification par affinité contre l'antigène
Tampon de stockage PBS only
Conditions de stockageStore at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

FAT2 (FAT atypical cadherin 2), also known as CDHF8. The gene product is a member of the cadherin superfamily, a group of integral membrane proteins characterized by the presence of cadherin-type repeats. This protein most likely functions as a cell adhesion molecule, controlling cell proliferation and playing an important role in cerebellum development. Expressed in epidermal keratinocytes, infant brain, cerebellum, and also in a variety of tumors, such as pancreatic cancer, diffuse type gastric cancer, ovarian cancer, esophageal cancer, skin squamous cell carcinoma, head and neck cancer. Not expressed in melanoma cell line A375 cells, normal epidermal melanocytes or normal dermal fibroblasts. Expressed in epidermal keratinocytes and squamous cell carcinoma (at protein level). The molecular weight of FAT2 is 473 kDa. The huge molecular masses (about 500-600 kDa) have hindered studies of the molecular aspects of itself roles(PMID: 15923647).

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