Anticorps Polyclonal de lapin anti-FBX4

FBX4 Polyclonal Antibody for IP, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

IP, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 13855-1-PBS

Synonymes

FBXO4, F-box only protein 4, F box protein 4, F box only protein 4

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Galerie de données de validation

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  IP experiment of HeLa using 13855-1-AP (same clone as 13855-1-PBS)

  IP result of anti-FBX4 (IP:13855-1-AP, 4ug; Detection:13855-1-AP 1:800) with HeLa cells lysate 1400 ug. This data was developed using the same antibody clone with 13855-1-PBS in a different storage buffer formulation.

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  IP experiment of A431 using 13855-1-AP (same clone as 13855-1-PBS)

  IP result of anti-FBX4 (IP:13855-1-AP, 4ug; Detection:13855-1-AP 1:800) with A431 cells lysate 1040 ug. This data was developed using the same antibody clone with 13855-1-PBS in a different storage buffer formulation.

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Informations sur le produit

13855-1-PBS cible FBX4 dans les applications de IP, Indirect ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: FBX4 Protéine recombinante Ag4829
• Nom complet: F-box protein 4
• Masse moléculaire calculée: 44 kDa
• Poids moléculaire observé: 38 kDa
• Numéro d’acquisition GenBank: BC048098
• Symbole du gène: FBXO4/FBX4
• Identification du gène (NCBI): 26272
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

FBX4 (F-Box Protein 4), also known as FBXO4, is a member of the F-box protein family. FBX4 is involved in the ubiquitination of various target proteins, leading to their degradation. It has been shown to regulate the cell cycle by targeting proteins such as cyclin D1 for ubiquitination and degradation. Mutations in FBX4 have been linked to various diseases, including spermatogenic failure and esophageal cancer. In cancer, FBX4 has been shown to act as a tumor suppressor. Loss of FBX4 function can lead to increased cell proliferation and tumor development. For example, FBX4 knockout mice have been shown to develop various tumors, including lymphoblastic lymphoma and mammary carcinoma.

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