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Anticorps Polyclonal de lapin anti-FBXL6

FBXL6 Polyclonal Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 33265-1-PBS

Synonymes

FBL6, FBL6A, F-box and leucine-rich repeat protein 6, F-box protein FBL6, F-box/LRR-repeat protein 6

Galerie de données de validation

Filter:
  • Western Blot (WB) analysis of various lysates using FBXL6 Polyclonal antibody (33265-1-AP)

    WB analysis using 33265-1-AP (same clone as 33265-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 33265-1-AP (FBXL6 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 33265-1-PBS in a different storage buffer formulation.

Informations sur le produit

33265-1-PBS cible FBXL6 dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain

Réactivité Humain
Hôte / Isotype Lapin / IgG
Clonalité Polyclonal
Type Anticorps
Immunogène FBXL6 Protéine recombinante Ag36604
Nom complet F-box and leucine-rich repeat protein 6
Masse moléculaire calculée59kDa，539aa
Poids moléculaire observé60 kDa
Numéro d’acquisition GenBankNM_012162.3
Symbole du gène FBXL6
Identification du gène (NCBI) 26233
Conjugaison Non conjugué
Forme Liquide
Méthode de purification Purification par affinité contre l'antigène
Tampon de stockage PBS only
Conditions de stockageStore at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

FBXL6 is an F-box/LRR-type E3 ubiquitin ligase that serves as the substrate-recognition subunit of the SCF complex. It stabilizes HSP90AA1 via K63-linked ubiquitination to activate c-MYC and drive hepatocellular carcinoma progression, while also degrading defective mitochondrial ribosomal proteins to preserve mitochondrial proteostasis. Its overexpression correlates with poor prognosis in renal and colorectal cancers and can promote cell proliferation by down-regulating RPL11 to activate the MDM2-p53 axis.

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