Anticorps Polyclonal de lapin anti-FBXL8

FBXL8 Polyclonal Antibody for IHC, IP, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, souris

Applications

IHC, IP, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 16505-1-PBS

Synonymes

FBL8, F-box and leucine-rich repeat protein 8, F-box protein FBL8, F-box/LRR-repeat protein 8

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Galerie de données de validation

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  IP experiment of HCT 116 using 16505-1-AP (same clone as 16505-1-PBS)

  IP result of anti-FBXL8 (IP:16505-1-AP, 4ug; Detection:16505-1-AP 1:500) with HCT 116 cells lysate 1920 ug. This data was developed using the same antibody clone with 16505-1-PBS in a different storage buffer formulation.

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  IHC staining of mouse heart using 16505-1-AP (same clone as 16505-1-PBS)

  Immunohistochemical analysis of paraffin-embedded mouse heart tissue slide using 16505-1-AP (FBXL8 antibody) at dilution of 1:100 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 16505-1-PBS in a different storage buffer formulation.

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  IHC staining of mouse heart using 16505-1-AP (same clone as 16505-1-PBS)

  Immunohistochemical analysis of paraffin-embedded mouse heart tissue slide using 16505-1-AP (FBXL8 antibody) at dilution of 1:100 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 16505-1-PBS in a different storage buffer formulation.

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Informations sur le produit

16505-1-PBS cible FBXL8 dans les applications de IHC, IP, Indirect ELISA et montre une réactivité avec des échantillons Humain, souris

• Réactivité: Humain, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: FBXL8 Protéine recombinante Ag9685
• Nom complet: F-box and leucine-rich repeat protein 8
• Masse moléculaire calculée: 374 aa, 41 kDa
• Poids moléculaire observé: 41 kDa
• Numéro d’acquisition GenBank: BC014414
• Symbole du gène: FBXL8
• Identification du gène (NCBI): 55336
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

FBXL8 is a conserved F-box protein that belongs to the ubiquitin ligase complex. It plays a significant role in various cellular processes, including tumorigenesis and metastasis. In colorectal cancer, FBXL8 promotes liver metastasis and stem-cell-like features by mediating ubiquitination and degradation of TP53. Additionally, FBXL8 has been shown to inhibit lymphoma growth and hematopoietic malignancies by targeting specific substrates for degradation. In the context of cardiac fibrosis, FBXL8 inhibits post-myocardial infarction cardiac fibrosis by regulating the ubiquitination of key proteins (PMID: 36855778, PMID: 33122824, PMID: 38615011).

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