Anticorps Polyclonal de lapin anti-FBXO38

FBXO38 Polyclonal Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, souris

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 31282-1-PBS

Synonymes

SP329, MOKA, Fbx38, F box protein 38, F box only protein 38

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Galerie de données de validation

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  WB analysis using 31282-1-AP (same clone as 31282-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 31282-1-AP (FBXO38 antibody) at dilution of 1:15000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 31282-1-PBS in a different storage buffer formulation.

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Informations sur le produit

31282-1-PBS cible FBXO38 dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain, souris

• Réactivité: Humain, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: FBXO38 Protéine recombinante Ag35444
• Nom complet: F-box protein 38
• Masse moléculaire calculée: 134kDa，1188aa
• Poids moléculaire observé: 140 kDa, 107 kDa
• Numéro d’acquisition GenBank: XM_005268513.1
• Symbole du gène: FBXO38
• Identification du gène (NCBI): 81545
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

F-box containing protein 38 (FBXO38; also known as MoKA) is a substrate receptor for SKP1-CUL1-dependent ubiquitin ligase (SCF). Initially, it was discovered as a modulator of transcription factor Krüppel-like factor 7 (KLF7) activity (PMID: 14729953). In addition, FBXO38 stability is controlled via ubiquitin-specific peptidase 7 (USP7), and FBXO38 protein expression was shown to be required for proper cytokinesis (PMID: 30804394). However, as a ubiquitin ligase, SCFFBXO38 is still insufficiently characterized. So far, the only potential substrate identified is programmed cell death 1 (PD-1) (PMID: 30487606, PMID: 35813202).

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