Anticorps Polyclonal de lapin anti-FBX4

FBX4 Polyclonal Antibody for IP, ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

IP, ELISA

Conjugaison

Non conjugué

N° de cat : 13855-1-AP

Synonymes

FBXO4, F-box only protein 4, F box protein 4, F box only protein 4

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Galerie de données de validation

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  IP experiment of HeLa using 13855-1-AP

  IP result of anti-FBX4 (IP:13855-1-AP, 4ug; Detection:13855-1-AP 1:800) with HeLa cells lysate 1400 ug.

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  IP experiment of A431 using 13855-1-AP

  IP result of anti-FBX4 (IP:13855-1-AP, 4ug; Detection:13855-1-AP 1:800) with A431 cells lysate 1040 ug.

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Applications testées

• Résultats positifs en IP: cellules HeLa, cellules A431

Dilution recommandée

• Immunoprécipitation (IP): IP : 0.5-4.0 ug for 1.0-3.0 mg of total protein lysate

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, check data in validation data gallery

Informations sur le produit

13855-1-AP cible FBX4 dans les applications de IP, ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: FBX4 Protéine recombinante Ag4829
• Nom complet: F-box protein 4
• Masse moléculaire calculée: 44 kDa
• Poids moléculaire observé: 38 kDa
• Numéro d’acquisition GenBank: BC048098
• Symbole du gène: FBXO4/FBX4
• Identification du gène (NCBI): 26272
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS with 0.02% sodium azide and 50% glycerol
• Conditions de stockage: Stocker à -20°C. Stable pendant un an après l'expédition. L'aliquotage n'est pas nécessaire pour le stockage à -20^oC Les 20ul contiennent 0,1% de BSA.

Informations générales

FBX4 (F-Box Protein 4), also known as FBXO4, is a member of the F-box protein family. FBX4 is involved in the ubiquitination of various target proteins, leading to their degradation. It has been shown to regulate the cell cycle by targeting proteins such as cyclin D1 for ubiquitination and degradation. Mutations in FBX4 have been linked to various diseases, including spermatogenic failure and esophageal cancer. In cancer, FBX4 has been shown to act as a tumor suppressor. Loss of FBX4 function can lead to increased cell proliferation and tumor development. For example, FBX4 knockout mice have been shown to develop various tumors, including lymphoblastic lymphoma and mammary carcinoma.

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