Anticorps Monoclonal anti-FBXW11

FBXW11 Monoclonal Antibody for WB, IHC, Indirect ELISA

Hôte / Isotype

Mouse / IgG1

Réactivité testée

Humain, rat, souris

Applications

WB, IHC, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

1F5A10

N° de cat : 68090-1-PBS

Synonymes

BTRC2, BTRCP2, Fbw11, FBW1B, FBXW11, FBXW1B, Homologous to Slimb protein, Hos, KIAA0696

---

Galerie de données de validation

• 

  WB analysis using 68090-1-Ig (same clone as 68090-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 68090-1-Ig (FBXW11 antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 68090-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human colon cancer using 68090-1-Ig (same clone as 68090-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human colon cancer tissue slide using 68090-1-Ig (FBXW11 antibody) at dilution of 1:500 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 68090-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human stomach cancer using 68090-1-Ig (same clone as 68090-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human stomach cancer tissue slide using 68090-1-Ig (FBXW11 antibody) at dilution of 1:500 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 68090-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human stomach cancer using 68090-1-Ig (same clone as 68090-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human stomach cancer tissue slide using 68090-1-Ig (FBXW11 antibody) at dilution of 1:500 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 68090-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human colon cancer using 68090-1-Ig (same clone as 68090-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human colon cancer tissue slide using 68090-1-Ig (FBXW11 antibody) at dilution of 1:500 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 68090-1-PBS in a different storage buffer formulation.

---

Informations sur le produit

68090-1-PBS cible FBXW11 dans les applications de WB, IHC, Indirect ELISA et montre une réactivité avec des échantillons Humain, rat, souris

• Réactivité: Humain, rat, souris
• Hôte / Isotype: Mouse / IgG1
• Clonalité: Monoclonal
• Type: Anticorps
• Immunogène: FBXW11 Protéine recombinante Ag3761
• Nom complet: F-box and WD repeat domain containing 11
• Masse moléculaire calculée: 542 aa, 61 kDa
• Poids moléculaire observé: 58-62 kDa
• Numéro d’acquisition GenBank: BC026213
• Symbole du gène: FBXW11
• Identification du gène (NCBI): 23291
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

FBXW11 (also known as HOS or β-TrCP2) is a member of F-box family proteins and plays critical role in regulating the ubiquitination of phosphorylated substrates. Abnormal expression of several FBXW11 is involved in the modulation of various biological events, such as cell cycle, differentiation, migration, inflammation, and apoptosis, through targeting multiple different substrates. For instance, FBXW11 could bind to the phosphorylated IκB and β-catenin, promoting their degradation via the ubiquitin-proteasome system. In addition, FBXW11 expression is markedly increased in mouse skin tumors and promotes tumor growth by activating the NF-κB signaling (PMID: 33640602). FBXW11 has 3 isoforms with the molecular mass of 58-62 kDa.

{{ptg:RelatedPrimaryAntibodies}}