Anticorps Polyclonal de lapin anti-FBXW4

FBXW4 Polyclonal Antibody for WB, IHC, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, souris

Applications

WB, IHC, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 10657-1-PBS

Synonymes

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Galerie de données de validation

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  WB analysis of mouse lung using 10657-1-AP (same clone as 10657-1-PBS)

  mouse lung tissue were subjected to SDS PAGE followed by western blot with 10657-1-AP (FBXW4 Antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 10657-1-PBS in a different storage buffer formulation.

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  WB analysis of mouse liver using 10657-1-AP (same clone as 10657-1-PBS)

  mouse liver tissue were subjected to SDS PAGE followed by western blot with 10657-1-AP (FBXW4 Antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 10657-1-PBS in a different storage buffer formulation.

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  IHC staining of human pancreas using 10657-1-AP (same clone as 10657-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human pancreas tissue slide using 10657-1-AP (FBXW4 Antibody) at dilution of 1:200 (under 40x lens). This data was developed using the same antibody clone with 10657-1-PBS in a different storage buffer formulation.

• 

  IHC staining of human pancreas using 10657-1-AP (same clone as 10657-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human pancreas tissue slide using 10657-1-AP (FBXW4 Antibody) at dilution of 1:200 (under 10x lens). This data was developed using the same antibody clone with 10657-1-PBS in a different storage buffer formulation.

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Informations sur le produit

10657-1-PBS cible FBXW4 dans les applications de WB, IHC, Indirect ELISA et montre une réactivité avec des échantillons Humain, souris

• Réactivité: Humain, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: FBXW4 Protéine recombinante Ag1047
• Nom complet: F-box and WD repeat domain containing 4
• Masse moléculaire calculée: 46 kDa
• Poids moléculaire observé: 50 kDa
• Numéro d’acquisition GenBank: BC007380
• Symbole du gène: FBXW4
• Identification du gène (NCBI): 6468
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

F-box proteins have been shown to be critical for the ubiquitin-mediated degradation of cellular regulatory proteins, and they are a family of eukaryotic proteins characterized by an approximately 40 amino acid motif. SCF complex, a class of ubiquitin ligases, consists of invariable components, Skp1 and Cullin, and variable components of F-box proteins, which have a primary role in determining substrate specificity. FBXW4, also known as SHFM3, encodes F-box and WD-40 domain-containing protein 4. Defects in SHFM3 are a cause of split-hand/foot malformation type 3 (SHFM3), an autosomal dominant disorder characterized by hypoplasia/aplasia of the central digits with fusion of the remaining digits.

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