Anticorps Recombinant de lapin anti-FGFR2/CD332

FGFR2/CD332 Recombinant Antibody for FC

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

FC

Conjugaison

Non conjugué

CloneNo.

241383D11

N° de cat : 98244-1-PBS

Synonymes

FGFR2, CFD1, CEK3, CD332, BFR 1

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Galerie de données de validation

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  FC experiment of Transfected HEK-293T using 98244-1-RR (same clone as 98244-1-PBS)

  1x10^6 HEK-293T cells or FGFR2/CD332 transfected HEK-293T cells were surface stained with 0.25 ug Anti-Human FGFR2/CD332 Rabbit Recombinant Antibody (98244-1-RR, Clone: 241383D11) and Multi-rAb CoraLite ® Plus 647-Goat Anti-Rabbit Recombinant Secondary Antibody (H+L) (RGAR005). Cells were not fixed. This data was developed using the same antibody clone with 98244-1-PBS in a different storage buffer formulation.

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  FC experiment of Transfected HEK-293T using 98244-1-RR (same clone as 98244-1-PBS)

  1x10^6 HEK-293T cells (left) or FGFR2/CD332 transfected HEK-293T cells (right) were surface stained with 0.25 ug Anti-Human FGFR2/CD332 Rabbit Recombinant Antibody (98244-1-RR, Clone:241383D11) (red) or Rabbit IgG Isotype Control Recombinant Antibody (98136-1-RR, Clone: 240953C9) (blue), and Multi-rAb CoraLite ® Plus 647-Goat Anti-Rabbit Recombinant Secondary Antibody (H+L) (RGAR005). Cells were not fixed. This data was developed using the same antibody clone with 98244-1-PBS in a different storage buffer formulation.

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  Affinity and Kinetic Characterization of 98244-1-RR

  Biolayer interferometry (BLl) kinetic assays of 98244-1-RR against Human FGFR2/CD332 were performed. The affinity constant is 1.69 nM.

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Informations sur le produit

98244-1-PBS cible FGFR2/CD332 dans les applications de FC et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: Protéine recombinante
• Nom complet: fibroblast growth factor receptor 2
• Masse moléculaire calculée: 92kd
• Numéro d’acquisition GenBank: NM_000141.4
• Symbole du gène: FGFR2
• Identification du gène (NCBI): 2263
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Protein A purfication
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C.

Informations générales

FGFR2 (Fibroblast growth factor receptor 2), also known as CD332, is a tyrosine-protein kinase that acts as a cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration, and apoptosis. Ligand binding leads to the activation of several signaling pathways, such as RAS, MAPK1/ERK2, MAPK3/ERK1, and the MAP Kinase signaling pathway, as well as the AKT1 signaling pathway. Mutations in the gene of FGFR2 are associated with Crouzon syndrome, Pfeiffer syndrome, Craniosynostosis, Apert syndrome, Jackson-Weiss syndrome, Beare-Stevenson cutis gyrata syndrome, Saethre-Chotzen syndrome, and syndromic craniosynostosis.

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