Anticorps Polyclonal de lapin anti-FGFR4

• Phare
• Validé par KD/KO

FGFR4 Polyclonal Antibody for WB, IHC, IF/ICC, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

WB, IHC, IF/ICC, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 11098-1-PBS

Synonymes

CD334, EC:2.7.10.1, FGFR 4, FGFR-4, JTK2

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Galerie de données de validation

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  WB analysis using 11098-1-AP (same clone as 11098-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 11098-1-AP (FGFR4 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 11098-1-PBS in a different storage buffer formulation.

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  IHC staining of human breast cancer using 11098-1-AP (same clone as 11098-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human breast cancer tissue slide using 11098-1-AP (FGFR4 antibody) at dilution of 1:200 (under 10x lens. Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 11098-1-PBS in a different storage buffer formulation.

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  IHC staining of human breast cancer using 11098-1-AP (same clone as 11098-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human breast cancer tissue slide using 11098-1-AP (FGFR4 antibody) at dilution of 1:200 (under 40x lens. Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 11098-1-PBS in a different storage buffer formulation.

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  IF Staining of HepG2 using 11098-1-AP (same clone as 11098-1-PBS)

  Immunofluorescent analysis of (-20℃ Ethanol) fixed HepG2 cells using 11098-1-AP (FGFR4 antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IgG(H+L). This data was developed using the same antibody clone with 11098-1-PBS in a different storage buffer formulation.

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Informations sur le produit

11098-1-PBS cible FGFR4 dans les applications de WB, IHC, IF/ICC, Indirect ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: FGFR4 Protéine recombinante Ag1573
• Nom complet: fibroblast growth factor receptor 4
• Masse moléculaire calculée: 88 kDa
• Poids moléculaire observé: 95, 100-110 kDa
• Numéro d’acquisition GenBank: BC011847
• Symbole du gène: FGFR4
• Identification du gène (NCBI): 2264
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

Fibroblast growth factor receptor 4 (FGFR4) is a member of a highly conserved tyrosine kinase family, along with FGFR1-3. This family consists of an intracellular tyrosine kinase domain, a single transmembrane domain, and extracellular ligand-binding domains (PMID: 32492514). FGFR4 is the predominant FGFR isoform present in human hepatocytes. FGFR4 has been proposed to play a role in the observed induction of hepatocyte proliferation and carcinogenesis by FGF19; however, contradicting evidence proposing a protective role for FGFR4 in suppressing hepatoma progression has also been proposed(PMID: 20018895). While the role of FGFR4 in cancer remains to be fully elucidated, several findings suggest that this receptor may be an important player in Hepatocellular carcinoma (HCC) development and/or progression(PMID: 10336501).

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