Anticorps Monoclonal anti-FGFR4

FGFR4 Monoclonal Antibody for WB, Indirect ELISA

Hôte / Isotype

Mouse / IgG1

Réactivité testée

Humain

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

1A2B5

N° de cat : 67800-1-PBS

Synonymes

CD334, FGFR 4, FGFR4, JTK2, TKF

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Galerie de données de validation

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  WB analysis using 67800-1-Ig (same clone as 67800-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 67800-1-Ig (FGFR4 antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 67800-1-PBS in a different storage buffer formulation.

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Informations sur le produit

67800-1-PBS cible FGFR4 dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Mouse / IgG1
• Clonalité: Monoclonal
• Type: Anticorps
• Immunogène: FGFR4 Protéine recombinante Ag17041
• Nom complet: fibroblast growth factor receptor 4
• Masse moléculaire calculée: 88 kDa
• Poids moléculaire observé: 100-110 kDa
• Numéro d’acquisition GenBank: BC011847
• Symbole du gène: FGFR4
• Identification du gène (NCBI): 2264
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine G
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

Fibroblast growth factor receptor 4 (FGFR4) is a member of a highly conserved tyrosine kinase family, along with FGFR1-3. This family consists of an intracellular tyrosine kinase domain, a single transmembrane domain, and extracellular ligand binding domains (PMID:32492514). FGFR4 is the predominant FGFR isoform present in human hepatocytes. FGFR4 has been proposed to play a role in the observed induction of hepatocyte proliferation and carcinogenesis by FGF19; however, contradicting evidence proposing a protective role for FGFR4 in suppressing hepatoma progression has also been proposed(PMID:20018895). While the role of FGFR4 in cancer remains to be fully elucidated, several findings suggest that this receptor may be an important player in Hepatocellular carcinoma (HCC) development and/or progression(PMID:10336501).

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