Anticorps Recombinant de lapin anti-FGFR4

FGFR4 Recombinant Antibody for FC

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

FC

Conjugaison

Non conjugué

CloneNo.

242713H4

N° de cat : 98383-2-PBS

Synonymes

CD334, EC:2.7.10.1, FGFR 4, FGFR-4, JTK2

---

Galerie de données de validation

• 

  FC experiment of HepG2 using 98383-2-RR (same clone as 98383-2-PBS)

  1x10^6 HepG2 cells(left) or A431 cells (right) were surface stained with 0.25 ug Anti-Human FGFR4 Rabbit RecAb (98383-2-RR, Clone:242713H4) and PE-Conjugated Goat Anti-Rabbit IgG(H+L)(red), or 0.25 ug Rabbit IgG Isotype Control RecAb (98136-2-RR, Clone: 240953A11) (blue). Cells were not fixed. This data was developed using the same antibody clone with 98383-2-PBS in a different storage buffer formulation.

---

Informations sur le produit

98383-2-PBS cible FGFR4 dans les applications de FC et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: Protéine recombinante
• Nom complet: fibroblast growth factor receptor 4
• Masse moléculaire calculée: 88 kDa
• Numéro d’acquisition GenBank: BC011847
• Symbole du gène: FGFR4
• Identification du gène (NCBI): 2264
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C.

Informations générales

Fibroblast growth factor receptor 4 (FGFR4) is a member of a highly conserved tyrosine kinase family, along with FGFR1-3. This family consists of an intracellular tyrosine kinase domain, a single transmembrane domain, and extracellular ligand binding domains (PMID:32492514). FGFR4 is the predominant FGFR isoform present in human hepatocytes. FGFR4 has been proposed to play a role in the observed induction of hepatocyte proliferation and carcinogenesis by FGF19; however, contradicting evidence proposing a protective role for FGFR4 in suppressing hepatoma progression has also been proposed(PMID:20018895). While the role of FGFR4 in cancer remains to be fully elucidated, several findings suggest that this receptor may be an important player in Hepatocellular carcinoma (HCC) development and/or progression (PMID:10336501).

{{ptg:RelatedPrimaryAntibodies}}