Anticorps Recombinant de lapin anti-FGFR4

FGFR4 Recombinant Antibody for FC

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

FC

Conjugaison

Non conjugué

CloneNo.

242713H4

N° de cat : 98383-2-RR

Synonymes

CD334, EC:2.7.10.1, FGFR 4, FGFR-4, JTK2

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Galerie de données de validation

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  FC experiment of HepG2 using 98383-2-RR

  1x10^6 HepG2 cells(left) or A431 cells (right) were surface stained with 0.25 ug Anti-Human FGFR4 Rabbit RecAb (98383-2-RR, Clone:242713H4) and PE-Conjugated Goat Anti-Rabbit IgG(H+L)(red), or 0.25 ug Rabbit IgG Isotype Control RecAb (98136-2-RR, Clone: 240953A11) (blue). Cells were not fixed.

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Applications testées

• Résultats positifs en cytométrie: cellules HepG2,

Dilution recommandée

Application	Dilution
This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, check data in validation data gallery

Informations sur le produit

98383-2-RR cible FGFR4 dans les applications de FC et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: Protéine recombinante
• Nom complet: fibroblast growth factor receptor 4
• Masse moléculaire calculée: 88 kDa
• Numéro d’acquisition GenBank: BC011847
• Symbole du gène: FGFR4
• Identification du gène (NCBI): 2264
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS with 0.09% sodium azide
• Conditions de stockage: Store at 2 - 8°C. Stable for one year after shipment.

Informations générales

Fibroblast growth factor receptor 4 (FGFR4) is a member of a highly conserved tyrosine kinase family, along with FGFR1-3. This family consists of an intracellular tyrosine kinase domain, a single transmembrane domain, and extracellular ligand binding domains (PMID:32492514). FGFR4 is the predominant FGFR isoform present in human hepatocytes. FGFR4 has been proposed to play a role in the observed induction of hepatocyte proliferation and carcinogenesis by FGF19; however, contradicting evidence proposing a protective role for FGFR4 in suppressing hepatoma progression has also been proposed(PMID:20018895). While the role of FGFR4 in cancer remains to be fully elucidated, several findings suggest that this receptor may be an important player in Hepatocellular carcinoma (HCC) development and/or progression (PMID:10336501).

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