Anticorps Monoclonal anti-FHIT

FHIT Monoclonal Antibody for Cytometric bead array, Indirect ELISA

Hôte / Isotype

Mouse / IgG1

Réactivité testée

Humain

Applications

Cytometric bead array, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

4D6G1

N° de cat : 66086-1-PBS

Synonymes

Adenosine 5'-monophosphoramidase FHIT, Adenylylsulfatase, Adenylylsulfate-ammonia adenylyltransferase, AP3A hydrolase, AP3Aase

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Galerie de données de validation

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  WB analysis of K-562 using 66086-1-Ig (same clone as 66086-1-PBS)

  K-562 cells were subjected to SDS PAGE followed by western blot with 66086-1-Ig (FHIT antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 66086-1-PBS in a different storage buffer formulation.

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  Cytometric bead array standard curve of MP51232-1

  Cytometric bead array standard curve of MP51232-1, FHIT Monoclonal Matched Antibody Pair, PBS Only. Capture antibody: 60833-1-PBS. Detection antibody: 66086-1-PBS. Standard:Ag14471. Range: 0.391-100 ng/mL.

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Informations sur le produit

66086-1-PBS cible FHIT dans les applications de Cytometric bead array, Indirect ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Mouse / IgG1
• Clonalité: Monoclonal
• Type: Anticorps
• Immunogène: FHIT Protéine recombinante Ag14471
• Nom complet: fragile histidine triad gene
• Masse moléculaire calculée: 147 aa, 17 kDa
• Poids moléculaire observé: 17 kDa
• Numéro d’acquisition GenBank: BC032336
• Symbole du gène: FHIT
• Identification du gène (NCBI): 2272
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

The candidate tumor suppressor gene, FHIT(Fragile histidine triad protein), encompasses the common human chromosomal fragile site at 3p14.2, the hereditary renal cancer translocation breakpoint, and cancer cell homozygous deletions. Fhit hydrolyzes dinucleotide 5',5'''-P1,P3-triphosphate in vitro and mutation of a central histidine abolishes hydrolase activity(PMID:9391102). FHIT has a major role in regulating beta-catenin-mediated gene transcription.

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