Anticorps Recombinant de lapin anti-FKBP5

FKBP5 Recombinant Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

250798G2

N° de cat : 86189-1-PBS

Synonymes

FKBP-51, 51 kDa FK506-binding protein, 54 kDa progesterone receptor-associated immunophilin, AIG6, Androgen-regulated protein 6

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Galerie de données de validation

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  WB analysis using 86189-1-RR (same clone as 86189-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 86189-1-RR (FKBP5 antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 86189-1-PBS in a different storage buffer formulation.

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  Affinity and Kinetic Characterization of 86189-1-RR

  Biolayer interferometry (BLl) kinetic assays of 86189-1-RR against Human FKBP5 were performed. The affinity constant is 4.32 nM.

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Informations sur le produit

86189-1-PBS cible FKBP5 dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: FKBP5 Protéine recombinante Ag5337
• Nom complet: FK506 binding protein 5
• Masse moléculaire calculée: 457 aa, 51 kDa
• Poids moléculaire observé: 51 kDa
• Numéro d’acquisition GenBank: BC042605
• Symbole du gène: FKBP5
• Identification du gène (NCBI): 2289
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

FKBP5, also known as FKBP51, belongs to the family of immunophilins, FK506 binding proteins (FKBPs). FKBP5 is a negative regulator of GR activity and plays a key role in the termination of the stress response by GRs. FKBP5 limits GR function by decreasing ligand-binding sensitivity, thereby delaying nuclear translocation and reducing GR-dependent transcriptional activity. The known functions of FKBP5 include the regulation of steroid hormone receptors, inhibiting apoptosis in cancer cells, promoting Akt1 dephosphorylation, and inhibiting the Akt1 pathways, to name a few. FKBP5 is widely expressed and the calculated molecular weight is 51 kDa (PMID: 21119664, PMID: 34077736, PMID: 37154033).

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