Anticorps Polyclonal de lapin anti-FLT3

FLT3 Polyclonal Antibody for WB, IP, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

WB, IP, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 30297-1-PBS

Synonymes

CD135, Fetal liver kinase-2, FL cytokine receptor, FLK2, FLK-2

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Galerie de données de validation

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  WB analysis using 30297-1-AP (same clone as 30297-1-PBS)

  THP-1 cells were subjected to SDS PAGE followed by western blot with 30297-1-AP (FLT3 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 30297-1-PBS in a different storage buffer formulation.

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  IP experiment of THP-1 using 30297-1-AP (same clone as 30297-1-PBS)

  IP result of anti-FLT3 (IP:30297-1-AP, 4ug; Detection:30297-1-AP 1:500) with THP-1 cells lysate 2720 ug. This data was developed using the same antibody clone with 30297-1-PBS in a different storage buffer formulation.

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Informations sur le produit

30297-1-PBS cible FLT3 dans les applications de WB, IP, Indirect ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: FLT3 Protéine recombinante Ag32898
• Nom complet: fms-related tyrosine kinase 3
• Masse moléculaire calculée: 112 kDa
• Poids moléculaire observé: 130 kDa, 150 kDa
• Numéro d’acquisition GenBank: BC126350
• Symbole du gène: FLT3
• Identification du gène (NCBI): 2322
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

FLT3 (also known as CD135 or FLK2) is a tyrosine-protein kinase that acts as a cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation, and survival of hematopoietic progenitor cells and of dendritic cells. FLT3 was originally identified by its expression in hematopoietic stem/progenitor cells (PMID: 7507245). It is important for the normal development of hematopoietic stem/progenitor cells. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia.

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