Anticorps Recombinant de lapin anti-FLT3/CD135

FLT3/CD135 Recombinant Antibody for FC

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

FC

Conjugaison

Non conjugué

CloneNo.

241414F8

N° de cat : 98106-1-PBS

Synonymes

FLT3, FLK2, FL cytokine receptor, Fetal liver kinase-2, EC:2.7.10.1

---

Galerie de données de validation

• 

  FC experiment of Reh using 98106-1-RR (same clone as 98106-1-PBS)

  1x10^6 Reh cells (left) or U-937 cells (right) were surface stained with 0.25 ug Anti-Human FLT3 Rabbit Recombinant Antibody (98106-1-RR, Clone:241414F8) and PE-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L) (red), or Isotype Control (blue). Cells were not fixed. This data was developed using the same antibody clone with 98106-1-PBS in a different storage buffer formulation.

• 

  Affinity and Kinetic Characterization of 98106-1-RR

  Biolayer interferometry (BLl) kinetic assays of 98106-1-RR against Human FLT3/CD135 were performed. The affinity constant is 1.25 nM.

---

Informations sur le produit

98106-1-PBS cible FLT3/CD135 dans les applications de FC et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: Protéine recombinante
• Nom complet: fms-related tyrosine kinase 3
• Masse moléculaire calculée: 993 aa, 113 kDa
• Numéro d’acquisition GenBank: BC036028
• Symbole du gène: FLT3
• Identification du gène (NCBI): 2322
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Protein A purfication
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C.

Informations générales

FLT3 (also known as CD135 or FLK2) is a tyrosine-protein kinase that acts as a cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation, and survival of hematopoietic progenitor cells and of dendritic cells. FLT3 was originally identified by its expression in hematopoietic stem/progenitor cells (PMID: 7507245). It is important for the normal development of hematopoietic stem/progenitor cells. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia.

{{ptg:RelatedPrimaryAntibodies}}