Anticorps Recombinant de lapin anti-Fas/CD95

Fas/CD95 Recombinant Antibody for FC

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

FC

Conjugaison

Non conjugué

CloneNo.

240340E11

N° de cat : 98034-1-PBS

Synonymes

FAS, APT1, Apoptosis-mediating surface antigen FAS, Apo-1 antigen, APO-1

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Galerie de données de validation

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  FC experiment of human PBMCs using 98034-1-RR (same clone as 98034-1-PBS)

  1x10^6 human PBMCs were surface stained with 0.25 ug Anti-Human Fas/CD95 Rabbit Recombinant Antibody (98034-1-RR, Clone: 240340E11) or 0.25 ug Isotype Control, and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were then stained with APC Anti-Human CD45RO (UCHL1) (APC-65150, Clone: UCHL1). Cells were not fixed. This data was developed using the same antibody clone with 98034-1-PBS in a different storage buffer formulation.

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  FC experiment of human PBMCs using 98034-1-RR (same clone as 98034-1-PBS)

  1x10^6 human PBMCs were surface stained with 0.25 ug Anti-Human Fas/CD95 Rabbit Recombinant Antibody (98034-1-RR, Clone: 240340E11) (red), or 0.25 ug Isotype Control (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed. This data was developed using the same antibody clone with 98034-1-PBS in a different storage buffer formulation.

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  Affinity and Kinetic Characterization of 98034-1-RR

  Biolayer interferometry (BLl) kinetic assays of 98034-1-RR against Human Fas/CD95 were performed. The affinity constant is 1.97 nM.

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Informations sur le produit

98034-1-PBS cible Fas/CD95 dans les applications de FC et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: Protéine recombinante
• Nom complet: Fas (TNF receptor superfamily, member 6)
• Masse moléculaire calculée: 38 kDa
• Numéro d’acquisition GenBank: NM_000043.6
• Symbole du gène: Fas/CD95
• Identification du gène (NCBI): 355
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Protein A purfication
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C.

Informations générales

FAS, also named as CD95, APO-1, APT1, FAS1 and TNFRSF6, is a receptor for TNFSF6/FASLG. It is a cell surface receptor belonging to the TNF receptor superfamily, can mediate apoptosis by ligation with an agonistic anti-Fas antibody or Fas ligand. Stimulation of Fas results in the aggregation of its intracellular death domains, leading to the formation of the death-inducing signaling complex (DISC). FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both.

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