Anticorps Polyclonal de lapin anti-FcRn-Specific

• Phare
• Validé par KD/KO

FcRn-Specific Polyclonal Antibody for WB, IHC, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

WB, IHC, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 16190-1-PBS

Synonymes

FCGRT, Neonatal Fc receptor, FCRN

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Galerie de données de validation

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  WB analysis using 16190-1-AP (same clone as 16190-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 16190-1-AP (FcRn-Specific antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 16190-1-PBS in a different storage buffer formulation.

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  IHC staining of human spleen using 16190-1-AP (same clone as 16190-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human spleen tissue slide using 16190-1-AP (FcRn-Specific antibody) at dilution of 1:1000 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 16190-1-PBS in a different storage buffer formulation.

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  IHC staining of human spleen using 16190-1-AP (same clone as 16190-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human spleen tissue slide using 16190-1-AP (FcRn-Specific antibody) at dilution of 1:1000 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 16190-1-PBS in a different storage buffer formulation.

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  IHC staining of human liver using 16190-1-AP (same clone as 16190-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human liver tissue slide using 16190-1-AP (FcRn-Specific antibody) at dilution of 1:1000 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 16190-1-PBS in a different storage buffer formulation.

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Informations sur le produit

16190-1-PBS cible FcRn-Specific dans les applications de WB, IHC, Indirect ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: Peptide
• Nom complet: Fc fragment of IgG, receptor, transporter, alpha
• Masse moléculaire calculée: 40 kDa
• Poids moléculaire observé: 40 kDa
• Numéro d’acquisition GenBank: NM_004107
• Symbole du gène: FcRn
• Identification du gène (NCBI): 2217
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

The neonatal Fc receptor for IgG (FcRn) is a membrane-associated receptor which acts as a key determinant of IgG homeostasis. FcRn is similar in structure to major histocompatibility class I molecules. It is a heterodimer composed of a alpha chain associated with β2-microglobulin. FcRn transfers IgG from the mother to the fetus across the placenta and the proximal small intestine. In addition, throughout life, FcRn protects IgG from degradation and thus regulates the serum half-life of IgG (PMID: 17703228).

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