Anticorps Recombinant de lapin anti-Fetuin-A/AHSG

Fetuin-A/AHSG Recombinant Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

1E4

N° de cat : 80793-1-PBS

Synonymes

AHSG, Fetuin-A, Alpha 2 Z globulin, alpha 2 HS glycoprotein, AHS

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Galerie de données de validation

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  WB analysis of human plasma using 80793-1-RR (same clone as 80793-1-PBS)

  human plasma were subjected to SDS PAGE followed by western blot with 80793-1-RR (Fetuin-A antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 80793-1-PBS in a different storage buffer formulation.

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  Affinity and Kinetic Characterization of 80793-1-RR

  Biolayer interferometry (BLl) kinetic assays of 80793-1-RR against Human AHSG were performed. The affinity constant is 5.52 nM.

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Informations sur le produit

80793-1-PBS cible Fetuin-A/AHSG dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: Fetuin-A/AHSG Protéine recombinante Ag9853
• Nom complet: alpha-2-HS-glycoprotein
• Masse moléculaire calculée: 367 aa, 39 kDa
• Poids moléculaire observé: 58 kDa
• Numéro d’acquisition GenBank: BC048198
• Symbole du gène: Fetuin-A
• Identification du gène (NCBI): 197
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

Fetuin-A, also named as Alpha2-HS glycoprotein (AHSG), is a member of cystatin superfamily of protease inhibitors. It is a highly expressed glycoprotein in various fetal tissues whereas it is mainly expressed by the liver in adults. Fetuin A, an extracellular inhibitor of transforming growth factor β, is a profibrogenic stimulus in liver disease. Circulating fetuin-A may be a beneficial serum biomarker in the detection of liver and vascular fibrosis progression in patients with non-alcoholic fatty liver disease. It is also involved in several functions, such as endocytosis, brain development and the formation of bone tissue. Fetuin-A exerts its effects on the cardiovascular system by two different mechanisms. On the one hand it inhibits ins signaling and induces ins resistance contributing to the onset of atherosclerosis and on the other hand it inhibits calcium deposition and protects from vascular calcification.

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