Anticorps Polyclonal de lapin anti-GALNT8

GALNT8 Polyclonal Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 24025-1-PBS

Synonymes

pp GaNTase 8, GALNAC T8

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Galerie de données de validation

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  WB analysis using 24025-1-AP (same clone as 24025-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 24025-1-AP (GALNT8 antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 24025-1-PBS in a different storage buffer formulation.

• 

  WB analysis using 24025-1-AP (same clone as 24025-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 24025-1-AP (GALNT8 antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 24025-1-PBS in a different storage buffer formulation.

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Informations sur le produit

24025-1-PBS cible GALNT8 dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: GALNT8 Protéine recombinante Ag21185
• Nom complet: UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 8 (GalNAc-T8)
• Masse moléculaire calculée: 637 aa, 73 kDa
• Poids moléculaire observé: 73 kDa, 95 kDa
• Numéro d’acquisition GenBank: BC140889
• Symbole du gène: GALNT8
• Identification du gène (NCBI): 26290
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

GALNT8 (Probable polypeptide N-acetylgalactosaminyltransferase 8) is a member of the UDP-GalNAc polypeptide N-acetylgalactosaminyl transferase (ppGaNTase) family, which initiates mucin-like O-linked protein glycosylation in the Golgi apparatus. The tissue distribution of GALNT8 is high in the heart, skeletal muscle, kidney and liver; moderate in the placenta, small intestine, leukocyte and lung; and weak in the brain, colon, thymus and spleen (PMID: 34576978). The overexpression of GALNT8 significantly promotes the cell cycle and proliferation of CRC cell lines and correlates with poor prognosis in patients with CRC. GALNT8 encodes a 637-amino-acid type-II membrane protein (GalNAc-T8). The detected molecular weight of GALNT8 (95 kDa) is much higher than the theoretical molecular weight (70 kDa) due to three N-GlcNAc sites (N85, N107 and N160) (PMID: 34743989, 34239555).

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