Anticorps Polyclonal de lapin anti-GALR2

GALR2 Polyclonal Antibody for WB, IHC, IF/ICC, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

WB, IHC, IF/ICC, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 29909-1-PBS

Synonymes

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Galerie de données de validation

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  WB analysis using 29909-1-AP (same clone as 29909-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 29909-1-AP (GALR2 antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 29909-1-PBS in a different storage buffer formulation.

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  IHC staining of human pancreas cancer using 29909-1-AP (same clone as 29909-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human pancreas cancer tissue slide using 29909-1-AP (GALR2 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 29909-1-PBS in a different storage buffer formulation.

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  IHC staining of human pancreas cancer using 29909-1-AP (same clone as 29909-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human pancreas cancer tissue slide using 29909-1-AP (GALR2 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 29909-1-PBS in a different storage buffer formulation.

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  IF Staining of HepG2 using 29909-1-AP (same clone as 29909-1-PBS)

  Immunofluorescent analysis of (4% PFA) fixed HepG2 cells using GALR2 antibody (29909-1-AP) at dilution of 1:200 and CoraLite®488-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L). This data was developed using the same antibody clone with 29909-1-PBS in a different storage buffer formulation.

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Informations sur le produit

29909-1-PBS cible GALR2 dans les applications de WB, IHC, IF/ICC, Indirect ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: GALR2 Protéine recombinante Ag31762
• Nom complet: galanin receptor 2
• Masse moléculaire calculée: 42KD
• Poids moléculaire observé: 42-50 kDa
• Numéro d’acquisition GenBank: NM_003857
• Symbole du gène: GALR2
• Identification du gène (NCBI): 8811
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

Galanin receptor type 2 (GALR2) is a receptor for galanin, GALP, and the hormone SPX1 (PMID:24517231). It is an important neuromodulator present in the brain, gastrointestinal system, and hypothalamo-pituitary axis. Activation of the GALR2 may protect the hippocampus from neuronal damage (PMID: 17263796). It is a 30-amino acid non-C-terminally amidated peptide that potently stimulates growth hormone secretion, inhibits cardiac vagal slowing of heart rate, abolishes sinus arrhythmia, and inhibits postprandial gastrointestinal motility. The activity of this receptor is mediated by G proteins that activate the phospholipase C/protein kinase C pathway (via G(q)) and that inhibits adenylyl cyclase. GALR2 has a calculated molecular weight of 42 kDa.

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