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Anticorps Recombinant de lapin anti-GCGR

GCGR Recombinant Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, souris

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

241501C4

N° de cat : 84237-5-PBS

Synonymes

glucagon receptor, GL-R, GL R, GGR, 241501C4

Galerie de données de validation

Filter:
  • Western Blot (WB) analysis of various lysates using GCGR Recombinant antibody (84237-5-RR)

    WB analysis using 84237-5-RR (same clone as 84237-5-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 84237-5-RR (GCGR antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 84237-5-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 84237-5-RR

    Affinity and Kinetic Characterization of 84237-5-RR

    Biolayer interferometry (BLl) kinetic assays of 84237-5-RR against Human GCGR were performed. The affinity constant is 71.6 pM.

Informations sur le produit

84237-5-PBS cible GCGR dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain, souris

Réactivité Humain, souris
Hôte / Isotype Lapin / IgG
Clonalité Recombinant
Type Anticorps
Immunogène GCGR Protéine recombinante Ag24861
Nom complet glucagon receptor
Masse moléculaire calculée 477 aa, 54 kDa
Poids moléculaire observé62-68 kDa
Numéro d’acquisition GenBankBC104854
Symbole du gène GCGR
Identification du gène (NCBI) 2642
Conjugaison Non conjugué
Forme Liquide
Méthode de purification Protein A purfication
Tampon de stockage PBS only
Conditions de stockageStore at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

Glucagon receptor (GCGR) is a secretin-like (class B) family of G-protein coupled receptors (GPCRs). It plays an important role in elevating the glucose concentration in the blood and has thus become one of the promising therapeutic targets for treating type 2 diabetes mellitus (PMID: 26236379). GCGR is a 62-kDa glycoprotein that contains at least four N-linked oligosaccharide chains (PMID: 2174441; 15245877). Defects in the gene of GCGR cause non-insulin-dependent diabetes mellitus (NIDDM).

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