Anticorps Recombinant de lapin anti-GIRK2

GIRK2 Recombinant Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, rat, souris

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

250605D1

N° de cat : 86016-1-PBS

Synonymes

KCNJ6, BIR1, G protein-activated inward rectifier potassium channel 2, GIRK 2, GIRK-2

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Galerie de données de validation

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  WB analysis using 86016-1-RR (same clone as 86016-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 86016-1-RR (KCNJ6 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 86016-1-PBS in a different storage buffer formulation.

• 

  WB analysis using 86016-1-RR (same clone as 86016-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 86016-1-RR (KCNJ6 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 86016-1-PBS in a different storage buffer formulation.

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  Affinity and Kinetic Characterization of 86016-1-RR

  Biolayer interferometry (BLl) kinetic assays of 86016-1-RR against Human GIRK2 were performed. The affinity constant is 0.372 nM.

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Informations sur le produit

86016-1-PBS cible GIRK2 dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain, rat, souris

• Réactivité: Humain, rat, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: GIRK2 Protéine recombinante Ag16344
• Nom complet: potassium inwardly-rectifying channel, subfamily J, member 6
• Masse moléculaire calculée: 423 aa, 48 kDa
• Poids moléculaire observé: 45-48 kDa
• Numéro d’acquisition GenBank: BC101547
• Symbole du gène: GIRK2
• Identification du gène (NCBI): 3763
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

GIRK2 (also known as Kir3.2), encoded by KCNJ6 gene, is a member of the G protein-coupled inwardly-rectifying potassium channel (GIRK, Kir3) family of inward rectifier potassium channels. GIRK channels are activated following stimulation of G protein-coupled receptors (PMID: 26422984). They play important roles in regulating cellular excitabilities in the heart and brain (PMID: 31043612). Mutations in KCNJ6 gene are associated with Keppen-Lubinsky Syndrome (PMID: 25620207).

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