Anticorps Recombinant de lapin anti-GITR/TNFRSF18

GITR/TNFRSF18 Recombinant Antibody for FC

Hôte / Isotype

Lapin / IgG

Réactivité testée

souris

Applications

FC

Conjugaison

Non conjugué

CloneNo.

250666B12

N° de cat : 98466-3-PBS

Synonymes

CD357, GITR, Tnfrsf18, AITR, Glucocorticoid-induced TNFR-related protein

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Galerie de données de validation

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  FC experiment of mouse splenocytes using 98466-3-RR (same clone as 98466-3-PBS)

  1x10^6 mouse splenocytes were surface stained with 0.25 ug Anti-Mouse GITR/TNFRSF18 Rabbit RecAb (98466-3-RR, Clone: 250666B12) or 0.25 ug Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were then stained with APC Anti-Mouse CD25/IL-2RA (PC61.5) (APC-65137, Clone: PC61.5). CD4+ cells were pre-gated for analysis. Cells were not fixed. This data was developed using the same antibody clone with 98466-3-PBS in a different storage buffer formulation.

• 

  FC experiment of mouse splenocytes using 98466-3-RR (same clone as 98466-3-PBS)

  1x10^6 mouse splenocytes were surface stained with 0.25 ug Anti-Mouse GITR/TNFRSF18 Rabbit RecAb (98466-3-RR, Clone:250666B12) (red) or 0.25 ug Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9) (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). CD4+ cells were pre-gated for analysis. Cells were not fixed. This data was developed using the same antibody clone with 98466-3-PBS in a different storage buffer formulation.

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Informations sur le produit

98466-3-PBS cible GITR/TNFRSF18 dans les applications de FC et montre une réactivité avec des échantillons souris

• Réactivité: souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: GITR/TNFRSF18 Protéine recombinante Eg3695
• Nom complet: tumor necrosis factor receptor superfamily, member 18
• Masse moléculaire calculée: 25kDa
• Numéro d’acquisition GenBank: NM_009400.2
• Symbole du gène: CD357
• Identification du gène (NCBI): 21936
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C.

Informations générales

Glucocorticoid-induced TNFR-related protein (GITR), also known as CD357 or TNFRSF18, is a member of the tumor necrosis factor receptor (TNF-R) superfamily. GITR is expressed constitutively at high levels in T regulatory cells (Treg cells) and plays a key role in dominant immunological self-tolerance maintained by CD25+CD4+ regulatory T cells (PMID: 11812990). It is expressed at low levels on resting responder T cells. The expression of GITR on T cells can be upregulated upon activation (PMID: 15770698). GITR is activated by GITR ligand (GITRL) which is mainly expressed on APC. GITR-GITRL interactions could co-stimulate both responder T-cell functions and the suppressive functions of Treg cells (PMID: 16868552).

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