Anticorps Monoclonal anti-GLP1R

GLP1R Monoclonal Antibody for IF/ICC, ELISA

Hôte / Isotype

Mouse / IgG1

Réactivité testée

Humain, rat

Applications

IF/ICC, ELISA

Conjugaison

Non conjugué

CloneNo.

1A4G5

N° de cat : 60931-1-Ig

Synonymes

GLP 1 R, GLP 1 receptor, GLP 1R, GLP-1 receptor, GLP-1R

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Galerie de données de validation

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  IF Staining of rat pancreas using 60931-1-Ig

  FFPE-rat pancreas tissue was stained with GLP1R monoclonal antibody (Cat.NO. 60931-1-Ig) at 1:500 followed by detection with Multi-rAb® Polymer HRP-Goat Anti-Rabbit/Mouse Universal Recombinant Secondary Antibody (H+L) (Cat.NO. RGAU011). CoraLite®Plus 647-Tyramide Reagent (Cat.NO. PR30025) was used for signal development (purple). The slide was then conducted HIER in pH 9.0 Tris-EDTA buffer followed by staining with INS monoclonal antibody (66198-1-Ig, 1:5000). CoraLite®Plus 488-Tyramide Reagent (Cat.NO. PR30022) were used for signal development (green). Cell nucleus (blue) were stained with DAPI. The signal from each channel was captured and merged.

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Applications testées

• Résultats positifs en IF/ICC: tissu pancréatique de rat,

Dilution recommandée

• Immunofluorescence (IF)/ICC: IF/ICC : 1:250-1:1000

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, check data in validation data gallery

Informations sur le produit

60931-1-Ig cible GLP1R dans les applications de IF/ICC, ELISA et montre une réactivité avec des échantillons Humain, rat

• Réactivité: Humain, rat
• Hôte / Isotype: Mouse / IgG1
• Clonalité: Monoclonal
• Type: Anticorps
• Immunogène: GLP1R Protéine recombinante Ag23529
• Nom complet: glucagon-like peptide 1 receptor
• Masse moléculaire calculée: 463 aa, 53 kDa
• Numéro d’acquisition GenBank: BC112126
• Symbole du gène: GLP1R
• Identification du gène (NCBI): 2740
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine G
• Tampon de stockage: PBS with 0.02% sodium azide and 50% glycerol
• Conditions de stockage: Stocker à -20°C. Stable pendant un an après l'expédition. L'aliquotage n'est pas nécessaire pour le stockage à -20^oC Les 20ul contiennent 0,1% de BSA.

Informations générales

GLP1R (glucagon-like peptide-1 receptor) is a G protein-coupled receptor belonging to the secretin receptor superfamily, also known as class B (PMID:34911028). GLP1R is widely distributed in pancreatic islets, muscles, the gastrointestinal tract, the lung, liver, pancreas, and other tissues or organs (PMID:35989517). Moreover, GLP1R agonist has been reported to induce autophagy of EC (Endometrial carcinoma) cells, and high GLP1R expression may be associated with good prognosis of EC patients, suggesting that GLP1R is likely to participate in the progression of EC (PMID:29907137). Moreover, regarding the molecular weight of GLP1R, research shows that the bands at ~50 kDa and ~100 kDa belong to the monomer and dimer states of GLP1R (PMID: 28609478).

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