Anticorps Recombinant de lapin anti-GP2

GP2 Recombinant Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, rat, souris

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

242300F9

N° de cat : 84728-4-PBS

Synonymes

ZAP75, Pancreatic zymogen granule membrane protein GP-2, 242300F9

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Galerie de données de validation

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  WB analysis of mouse brain using 84728-4-RR (same clone as 84728-4-PBS)

  mouse brain tissue were subjected to SDS PAGE followed by western blot with 84728-4-RR (GP2 antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 84728-4-PBS in a different storage buffer formulation.

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Informations sur le produit

84728-4-PBS cible GP2 dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain, rat, souris

• Réactivité: Humain, rat, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: Protéine recombinante
• Nom complet: glycoprotein 2 (zymogen granule membrane)
• Masse moléculaire calculée: 59 kDa
• Poids moléculaire observé: 70 kDa
• Numéro d’acquisition GenBank: NM_001007240.2
• Symbole du gène: GP2
• Identification du gène (NCBI): 2813
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Protein A purfication
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

Pancreatic secretory granule membrane major glycoprotein (GP2) is the most abundant membrane component of zymogen granules secreted by pancreatic acinar cells (PMID: 8190715). GP2 associates with the plasma membrane via glycosylphosphatidylinositol (GPI) linkage. It is released from the membrane of mature zymogen granules by an enzymatic mechanism (PMID: 2011597). GP2 plays a role in defense against adhesive and invasive commensal bacteria during intestinal inflammation (PMID: 33594081). GP2 is preferentially expressed in acinar cell carcinomas of the pancreas but the glycoprotein can rarely also be expressed in a variety of other tumor entities (PMID: 36137400). The apparent molecular weight of GP2 is 70-100 kDa, which is larger than the calculated molecular weight, due to glycosylation (PMID: 19627615; 30186250).

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