Anticorps Polyclonal de lapin anti-GPR124

GPR124 Polyclonal Antibody for IHC, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, souris

Applications

IHC, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 20050-1-PBS

Synonymes

Tumor endothelial marker 5, TEM5, KIAA1531, G-protein coupled receptor 124, G protein coupled receptor 124

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Galerie de données de validation

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  IHC staining of mouse small intestine using 20050-1-AP (same clone as 20050-1-PBS)

  Immunohistochemical analysis of paraffin-embedded mouse small intestine tissue slide using 20050-1-AP (GPR124 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 20050-1-PBS in a different storage buffer formulation.

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  IHC staining of mouse lung using 20050-1-AP (same clone as 20050-1-PBS)

  Immunohistochemical analysis of paraffin-embedded mouse lung tissue slide using 20050-1-AP (GPR124 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 20050-1-PBS in a different storage buffer formulation.

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Informations sur le produit

20050-1-PBS cible GPR124 dans les applications de IHC, Indirect ELISA et montre une réactivité avec des échantillons Humain, souris

• Réactivité: Humain, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: Peptide
• Nom complet: G protein-coupled receptor 124
• Masse moléculaire calculée: 143 kDa
• Numéro d’acquisition GenBank: NM_032777
• Symbole du gène: GPR124
• Identification du gène (NCBI): 25960
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

GPR124, also named KIAA1531 and TEM5, belongs to the G-protein coupled receptor 2 family and LN-TM7 subfamily. GPR124 is an Orphan receptor. GPR124 is a Tumor endothelial marker (TEM) that is significantly up-regulated during angiogenesis and neoangiogenesis that are crucial for the growth of solid tumors localized on the cell surface and conserved across species are of particular interest for future development of anti-angiogenic therapies. GPR124 is a member of the adhesion family of G protein-coupled receptors and is localized on the surface of endothelial cells. GPR124 is a seven-pass transmembrane receptor, unlike TEM1, TEM7, and TEM8 which span the membrane once. Proteolytically processed soluble GPR124 mediates endothelial cell survival during angiogenesis by linking integrin to glycosaminoglycans. The antibody recognizes near the C-term of GPR124. The antibody can't recognize the isoform3 of GPR124.

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