Anticorps Polyclonal de lapin anti-GPR146

GPR146 Polyclonal Antibody for IHC, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, souris

Applications

IHC, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 16334-1-PBS

Synonymes

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Galerie de données de validation

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  IHC staining of mouse liver using 16334-1-AP (same clone as 16334-1-PBS)

  Immunohistochemical analysis of paraffin-embedded mouse liver tissue slide using 16334-1-AP (GPR146 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 16334-1-PBS in a different storage buffer formulation.

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  IHC staining of mouse kidney using 16334-1-AP (same clone as 16334-1-PBS)

  Immunohistochemical analysis of paraffin-embedded mouse kidney tissue slide using 16334-1-AP (GPR146 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 16334-1-PBS in a different storage buffer formulation.

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Informations sur le produit

16334-1-PBS cible GPR146 dans les applications de IHC, Indirect ELISA et montre une réactivité avec des échantillons Humain, souris

• Réactivité: Humain, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: GPR146 Protéine recombinante Ag9456
• Nom complet: G protein-coupled receptor 146
• Masse moléculaire calculée: 333 aa, 37 kDa
• Numéro d’acquisition GenBank: BC014241
• Symbole du gène: GPR146
• Identification du gène (NCBI): 115330
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

As a member of GPCRs, GPR146 (G protein-coupled receptor 146) was initially discovered as a c-peptide signal body. GPR146 may act as a c peptide receptor to interact with proinsulin c-peptide to regulate insulin levels (PMID: 37926274). Mechanically, GPR146 induces hepatic sterol regulatory element binding protein 2 (SREBP2) via the activation of extracellular signal-regulated kinase 1/2 (ERK1/2) signaling, consequently resulting in hepatic low-density lipoprotein (VLDL) secretion (PMID: 32491159).

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