Anticorps Recombinant de lapin anti-GPSM2

GPSM2 Recombinant Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

250793G2

N° de cat : 86175-1-PBS

Synonymes

G protein signaling modulator 2, G-protein-signaling modulator 2, LGN, Pins

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Galerie de données de validation

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  WB analysis using 86175-1-RR (same clone as 86175-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 86175-1-RR (GPSM2 antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 86175-1-PBS in a different storage buffer formulation.

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  Affinity and Kinetic Characterization of 86175-1-RR

  Biolayer interferometry (BLl) kinetic assays of 86175-1-RR against Human GPSM2 were performed. The affinity constant is 0.967 nM.

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Informations sur le produit

86175-1-PBS cible GPSM2 dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: GPSM2 Protéine recombinante Ag25195
• Nom complet: G-protein signaling modulator 2 (AGS3-like, C. elegans)
• Masse moléculaire calculée: 75 kDa
• Poids moléculaire observé: 70-77 kDa
• Numéro d’acquisition GenBank: BC027732
• Symbole du gène: GPSM2
• Identification du gène (NCBI): 29899
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

GPSM2 belongs to a family of proteins that modulate activation of G proteins. GPSM2 assists in the exchange of guanine nucleotides, and allows extracellular signals to be transmitted to cells via cell surface, and ultimately plays a key role in the activation of G-proteins. Therefore, GPSM2 is a critical factor for the stability of cell division. Some recent studies have shown that GPSM2 messenger RNA (mRNA) is overexpressed and plays a positive role in the development of certain tumors, such as liver cancer, pancreatic cancer, breast cancer. It also plays a role in neuroblast division and in the development of normal hearing. Mutations in GPSM2 are associated with autosomal recessive nonsyndromic deafness (DFNB82), which is a form of non-syndromic deafness characterized by prelingual, bilateral, severe, sensorineural hearing loss.

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