Anticorps Polyclonal de lapin anti-GRIN2B

GRIN2B Polyclonal Antibody for ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, rat, souris

Applications

WB, IF, ELISA

Conjugaison

Non conjugué

Publications(8)

N° de cat : 19954-1-AP

Synonymes

GluN2B, GRIN2B, hNR3, NMDAR2B, NR2B, NR3

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Galerie de données de validation

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Applications publiées

• WB: See 8 publications below
• IF: See 1 publications below

Informations sur le produit

19954-1-AP cible GRIN2B dans les applications de WB, IF, ELISA et montre une réactivité avec des échantillons Humain, rat, souris

• Réactivité: Humain, rat, souris
• Réactivité citée: rat, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: Peptide
• Nom complet: glutamate receptor, ionotropic, N-methyl D-aspartate 2B
• Masse moléculaire calculée: 166 kDa
• Numéro d’acquisition GenBank: NM_000834
• Symbole du gène: GRIN2B
• Identification du gène (NCBI): 2904
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS with 0.02% sodium azide and 50% glycerol
• Conditions de stockage: Stocker à -20°C. Stable pendant un an après l'expédition. L'aliquotage n'est pas nécessaire pour le stockage à -20^oC Les 20ul contiennent 0,1% de BSA.

Informations générales

GRIN2B (also known as GluN2B or NMDAR2B) is a member of the N-methyl-D-aspartate (NMDA) receptor family within the ionotropic glutamate receptor superfamily. NMDA receptors are widely expressed in the central nervous system and play a major role in excitatory synaptic transmission and plasticity (PMID: 23223336). NMDA receptors large multi-subunit complexes arranged into heteromeric assemblies composed of four homologous subunits within a repertoire of over 10 different subunits: eight GluN1 isoforms, four GluN2 subunits (A-D) and two GluN3 subunits (A and B) (PMID: 21395862). Naturally occurring mutations within GRIN2B gene are associated with neurodevelopmental disorders including autism spectrum disorder, attention deficit hyperactivity disorder, epilepsy, and schizophrenia.

Publications

Species	Application	Title
mouse	WB	J Neurosci; Microglial Tmem59 Deficiency Impairs Phagocytosis of Synapse and Leads to Autism-Like Behaviors in Mice.; Authors - Jian Meng
mouse	WB	Front Cell Dev Biol; RAB39B Deficiency Impairs Learning and Memory Partially Through Compromising Autophagy.; Authors - Mengxi Niu
mouse	WB	Front Cell Dev Biol; Profiling of Sexually Dimorphic Genes in Neural Cells to Identify Eif2s3y, Whose Overexpression Causes Autism-Like Behaviors in Male Mice.; Authors - Muxian Zhang
mouse	WB	Brain Res; Central nervous system-specific knockout of Brg1 causes growth retardation and neuronal degeneration.; Authors - Li Deng
rat	WB,IF	Neurochem Int; Protective effects of EphB2 on Aβ1-42 oligomer-induced neurotoxicity and synaptic NMDA receptor signaling in hippocampal neurons.; Authors - Geng Dandan D
mouse	WB	J Cell Mol Med; Increased level of RAB39B leads to neuronal dysfunction and behavioural changes in mice; Authors - Zijie Wang

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