Anticorps Recombinant de lapin anti-GSDMB

GSDMB Recombinant Antibody for WB, ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

WB, ELISA

Conjugaison

Non conjugué

CloneNo.

250653H4

N° de cat : 86148-1-RR

Synonymes

gasdermin B, Gasdermin like protein, Gasdermin-B, Gasdermin-B, C-terminal, Gasdermin-B, N-terminal

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Galerie de données de validation

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  WB analysis using 86148-1-RR

  Various lysates were subjected to SDS PAGE followed by western blot with 86148-1-RR (GSDMB antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours.

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Applications testées

• Résultats positifs en WB: cellules A431, cellules COLO 320, cellules MCF-7, cellules PC-3

Dilution recommandée

• Western Blot (WB): WB : 1:2000-1:10000

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, check data in validation data gallery

Informations sur le produit

86148-1-RR cible GSDMB dans les applications de WB, ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: Peptide
• Nom complet: gasdermin B
• Masse moléculaire calculée: 411 aa, 47 kDa
• Poids moléculaire observé: 47 kDa
• Numéro d’acquisition GenBank: BC025682
• Symbole du gène: GSDMB
• Identification du gène (NCBI): 55876
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS with 0.02% sodium azide and 50% glycerol
• Conditions de stockage: Stocker à -20°C. Stable pendant un an après l'expédition. L'aliquotage n'est pas nécessaire pour le stockage à -20^oC Les 20ul contiennent 0,1% de BSA.

Informations générales

GSDMB (Gasdermin B) is a member of the gasdermin family of proteins, which are involved in the regulation of pyroptosis, a form of programmed cell death. GSDMB plays a crucial role in immune responses, particularly against viral respiratory infections. It has also been implicated in various inflammatory and autoimmune diseases, as well as in cancer progression. GSDMB is known for its ability to induce pyroptosis by forming pores in cell membranes, leading to the release of inflammatory cytokines such as IL-1β and IL-18. This process is critical for combating infections and modulating immune responses. GSDMB can be activated by granzyme A (GZMA), which is released from natural killer (NK) cells and cytotoxic T lymphocytes (CTLs), leading to inflammatory cell death and influencing the tumor immune microenvironment. GSDMB also interacts with other signaling pathways, such as the ERK pathway, to regulate cell proliferation and death. (PMID: 40452932; 38066523; 36163066)

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