Anticorps Polyclonal de lapin anti-GUCY2D

GUCY2D Polyclonal Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, rat, souris

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 55127-1-PBS

Synonymes

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Galerie de données de validation

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  WB analysis of mouse brain using 55127-1-AP (same clone as 55127-1-PBS)

  mouse brain tissue were subjected to SDS PAGE followed by western blot with 55127-1-AP (GUCY2D antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 55127-1-PBS in a different storage buffer formulation.

• 

  WB analysis of human brain using 55127-1-AP (same clone as 55127-1-PBS)

  human brain tissue were subjected to SDS PAGE followed by western blot with 55127-1-AP (GUCY2D antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 55127-1-PBS in a different storage buffer formulation.

• 

  WB analysis of human brain using 55127-1-AP (same clone as 55127-1-PBS)

  human brain tissue were subjected to SDS PAGE followed by western blot with 55127-1-AP (GUCY2D antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 55127-1-PBS in a different storage buffer formulation.

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Informations sur le produit

55127-1-PBS cible GUCY2D dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain, rat, souris

• Réactivité: Humain, rat, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: Peptide
• Nom complet: guanylate cyclase 2D, membrane (retina-specific)
• Masse moléculaire calculée: 120 kDa
• Poids moléculaire observé: 120 kDa, 95 kDa
• Numéro d’acquisition GenBank: NM_000180
• Symbole du gène: GUCY2D
• Identification du gène (NCBI): 3000
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

GUCY2D, also named as CORD6, GUC1A4, GUC2D, RETGC, RETGC1 and ROS-GC, belongs to the adenylyl cyclase class-4/guanylyl cyclase family. It probably plays a specific functional role in the rods and/or cones of photoreceptors. It may be the enzyme involved in the resynthesis of cGMP required for recovery of the dark state after phototransduction. A number of nonsense and frameshift mutations in the GUCY2D gene have been identified in LCA1 patients. Defects in GUCY2D are the cause of cone-rod dystrophy type 6 (CORD6). GUCY2D is responsible for many reported cases of autosomal dominant CRDs. The antibody is specific to GUCY2D.

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