Anticorps Recombinant de lapin anti-Granzyme A

Granzyme A Recombinant Antibody for IF/ICC, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

IF/ICC, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

241979B8

N° de cat : 84583-3-PBS

Synonymes

GrA, GZMA, Fragmentin 1, EC:3.4.21.78, Cytotoxic T-lymphocyte proteinase 1

---

Galerie de données de validation

• 

  IF Staining of Jurkat using 84583-3-RR (same clone as 84583-3-PBS)

  Immunofluorescent analysis of (4% PFA) fixed Jurkat cells using GZMA antibody (84583-3-RR, Clone: 241979B8 ) at dilution of 1:250 and CoraLite®488-Conjugated Goat Anti-Rabbit IgG(H+L) (SA00013-2). This data was developed using the same antibody clone with 84583-3-PBS in a different storage buffer formulation.

---

Informations sur le produit

84583-3-PBS cible Granzyme A dans les applications de IF/ICC, Indirect ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: Granzyme A Protéine recombinante Ag1818
• Nom complet: granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
• Masse moléculaire calculée: 29 kDa
• Numéro d’acquisition GenBank: BC015739
• Symbole du gène: Granzyme A
• Identification du gène (NCBI): 3001
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Protein A purfication
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

Granzyme A(GrA, a tryptase) is necessary for target cell lysis in cell-mediated immune responses. It activates mitochondrial outer membrane permeabilization- and caspase-independent cell death pathways by cleaving the mitochondrial complex I component NDUFS3after lys56. Among serine proteases GrA has an unique quaternary structure consisting of a disulphide-linked homodimer of 60kDa linked via Cys93.(PMID: 12819769) This protein has 2 isoforms produced by alternative promoter usage with the MW of 29 and 27 kDa.

{{ptg:RelatedPrimaryAntibodies}}