Anticorps Polyclonal de lapin anti-HAMP

HAMP Polyclonal Antibody for WB, IP, ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

WB, IP, ELISA

Conjugaison

Non conjugué

N° de cat : 26237-1-PBS

Synonymes

HEPC, Hepc20, Hepc25 Hepcidin 20, HEPCIDIN, hepcidin antimicrobial peptide

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Galerie de données de validation

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  WB analysis using 26237-1-AP (same clone as 26237-1-PBS)

  HepG2 cells lysate was subjected to SDS PAGE followed by western blot with 26237-1-AP (HAMP antibody) at dilution of 1:400 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 26237-1-PBS in a different storage buffer formulation.

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  IP experiment of HepG2 using 26237-1-AP (same clone as 26237-1-PBS)

  IP result of anti-HAMP (IP:26237-1-AP, 4ug; Detection:26237-1-AP 1:500) with HepG2 cells lysate 1480 ug. This data was developed using the same antibody clone with 26237-1-PBS in a different storage buffer formulation.

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Informations sur le produit

26237-1-PBS cible HAMP dans les applications de WB, IP, ELISA et montre une réactivité avec des échantillons Humain

• Réactivité: Humain
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: HAMP Protéine recombinante Ag24065
• Nom complet: hepcidin antimicrobial peptide
• Masse moléculaire calculée: 9 kDa
• Poids moléculaire observé: 12 kDa
• Numéro d’acquisition GenBank: BC020612
• Symbole du gène: HAMP
• Identification du gène (NCBI): 57817
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

Hepcidin (HAMP) is a liver-produced hormone that constitutes the main circulating regulator of iron absorption and distribution across tissues. It acts by promoting endocytosis and degradation of ferroportin/SLC40A1, leading to the retention of iron in iron-exporting cells and decreased flow of iron into plasma (PMID: 22682227; 29237594; 32814342). Hepcidin is an 84-amino acid prepropeptide, and is usually cleaved into three peptide types, hepcidin-20, hepcidin-22, and hepcidin-25, of which hepcidin-25 is the active form and plays important roles in regulating functional iron deficiency (PMID: 34262329).

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