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Anticorps Recombinant de lapin anti-HAPLN1

HAPLN1 Recombinant Antibody for WB, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, rat, souris

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

241588E9

N° de cat : 84374-4-PBS

Synonymes

Proteoglycan link protein, CRTL1, CRT1, Cartilage-linking protein 1, Cartilage-link protein

Galerie de données de validation

Filter:
  • Western Blot (WB) analysis of various lysates using HAPLN1 Recombinant antibody (84374-4-RR)

    WB analysis using 84374-4-RR (same clone as 84374-4-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 84374-4-RR (HAPLN1 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 84374-4-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 84374-4-RR

    Affinity and Kinetic Characterization of 84374-4-RR

    Biolayer interferometry (BLl) kinetic assays of 84374-4-RR against Human HAPLN1 were performed. The affinity constant is below 1 pM.

Informations sur le produit

84374-4-PBS cible HAPLN1 dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain, rat, souris

Réactivité Humain, rat, souris
Hôte / Isotype Lapin / IgG
Clonalité Recombinant
Type Anticorps
Immunogène HAPLN1 Protéine recombinante Ag25221
Nom complet hyaluronan and proteoglycan link protein 1
Masse moléculaire calculée 40 kDa
Poids moléculaire observé40-45 kDa
Numéro d’acquisition GenBankBC057808
Symbole du gène HAPLN1
Identification du gène (NCBI) 1404
Conjugaison Non conjugué
Forme Liquide
Méthode de purification Protein A purfication
Tampon de stockage PBS only
Conditions de stockageStore at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

HAPLN1 (hyaluronan and proteoglycan link protein 1), also known as CRTL1. It is expected to be located in the cytoplasm and extracellular, and the protein is mainly expressed in placenta and small intestine. The calculated molecular weight of HAPLN1 is 40 kDa. HAPLN1 binds to aggrecan on the hyaluronic chain, stabilizing the aggregates and thus increasing compression resistance and shock absorption. HAPLN1 also functions as a growth factor, up regulating aggrecan and type II collagen synthesis in cartilage. It seems to be an essential part of cartilage homeostasis and may also contribute to homeostasis in the disc tissue (PMID: 23537453). It is reported in the literature that it is a double band.(PMID: 26341258)

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