Anticorps Monoclonal anti-HDAC3

HDAC3 Monoclonal Antibody for WB, Indirect ELISA

Hôte / Isotype

Mouse / IgG2b

Réactivité testée

Humain, rat, souris

Applications

WB, Indirect ELISA

Conjugaison

Non conjugué

CloneNo.

3E8F10

N° de cat : 67151-1-PBS

Synonymes

HD3, HDAC, HDAC3, histone deacetylase 3, RPD3, RPD3 2, SMAP45

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Galerie de données de validation

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  WB analysis using 67151-1-Ig (same clone as 67151-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 67151-1-Ig (HDAC3 antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 67151-1-PBS in a different storage buffer formulation.

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  WB analysis of HSC-T6 using 67151-1-Ig (same clone as 67151-1-PBS)

  HSC-T6 cells were subjected to SDS PAGE followed by western blot with 67151-1-Ig (HDAC3 antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 67151-1-PBS in a different storage buffer formulation.

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Informations sur le produit

67151-1-PBS cible HDAC3 dans les applications de WB, Indirect ELISA et montre une réactivité avec des échantillons Humain, rat, souris

• Réactivité: Humain, rat, souris
• Hôte / Isotype: Mouse / IgG2b
• Clonalité: Monoclonal
• Type: Anticorps
• Immunogène: HDAC3 Protéine recombinante Ag28464
• Nom complet: histone deacetylase 3
• Masse moléculaire calculée: 49 kDa
• Poids moléculaire observé: 49 kDa
• Numéro d’acquisition GenBank: BC000614
• Symbole du gène: HDAC3
• Identification du gène (NCBI): 8841
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par protéine A
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. Histone deacetylase (HDAC) and histone acetyltransferase (HAT) are enzymes that regulate transcription by selectively deacetylating or acetylating the (-amino groups of lysines located near the amino termini of core histone proteins. At least 4 classes of HDAC were identified. HDAC3 is a class I HDAC. HDAC3 has histone deacetylase activity and may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. HDAC3 can also down-regulate p53 function and thus modulate cell growth and apoptosis. The gene encoding HDAC3 is regarded as a potential tumor suppressor gene.

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