Anticorps Recombinant de lapin anti-HER2/ErbB2

HER2/ErbB2 Recombinant Antibody for FC

Hôte / Isotype

Lapin / IgG

Réactivité testée

souris

Applications

FC

Conjugaison

Non conjugué

CloneNo.

241366E6

N° de cat : 98153-1-RR

Synonymes

Her2 / ErbB2, Her2, Erbb2, EC:2.7.10.1, CD340

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Galerie de données de validation

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  FC experiment of NIH/3T3 using 98153-1-RR

  1x10^6 NIH/3T3 cells were surface stained with 0.25 ug Anti-Mouse HER2/ErbB2 Rabbit Recombinant Antibody (98153-1-RR, Clone: 241366E6) (red) or Isotype Control (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed.

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  Affinity and Kinetic Characterization of 98153-1-RR

  Biolayer interferometry (BLl) kinetic assays of 98153-1-RR against Mouse HER2/ErbB2 were performed. The affinity constant is 1.50 nM.

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Applications testées

• Résultats positifs en cytométrie: cellules NIH/3T3,

Dilution recommandée

Application	Dilution
This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, check data in validation data gallery

Informations sur le produit

98153-1-RR cible HER2/ErbB2 dans les applications de FC et montre une réactivité avec des échantillons souris

• Réactivité: souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Recombinant
• Type: Anticorps
• Immunogène: Protéine recombinante
• Nom complet: v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
• Masse moléculaire calculée: 139 kDa
• Numéro d’acquisition GenBank: NM_001003817.1
• Symbole du gène: Erbb2
• Identification du gène (NCBI): 13866
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Protein A purfication
• Tampon de stockage: PBS with 0.09% sodium azide
• Conditions de stockage: Store at 2 - 8°C. Stable for one year after shipment.

Informations générales

HER2, also known as ErbB2, Neu, and CD340, is a 185-kDa transmembrane glycoprotein member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. It has no ligand-binding domain and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signaling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase.

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