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Anticorps Polyclonal de lapin anti-HIC2

HIC2 Polyclonal Antibody for WB, IP, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain

Applications

WB, IP, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 22788-1-PBS

Synonymes

Galerie de données de validation

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  • Western Blot (WB) analysis of Jurkat cells using HIC2 Polyclonal antibody (22788-1-AP)

    WB analysis of Jurkat using 22788-1-AP (same clone as 22788-1-PBS)

    Jurkat cells were subjected to SDS PAGE followed by western blot with 22788-1-AP (HIC2 Antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 22788-1-PBS in a different storage buffer formulation.

  • Immunoprecipitation (IP) experiment of Jurkat cells using HIC2 Polyclonal antibody (22788-1-AP)

    IP experiment of Jurkat using 22788-1-AP (same clone as 22788-1-PBS)

    IP result of anti-HIC2 (IP:22788-1-AP, 4ug; Detection:22788-1-AP 1:300) with Jurkat cells lysate 2400ug. This data was developed using the same antibody clone with 22788-1-PBS in a different storage buffer formulation.

Informations sur le produit

22788-1-PBS cible HIC2 dans les applications de WB, IP, Indirect ELISA et montre une réactivité avec des échantillons Humain

Réactivité Humain
Hôte / Isotype Lapin / IgG
Clonalité Polyclonal
Type Anticorps
Immunogène HIC2 Protéine recombinante Ag18789
Nom complet hypermethylated in cancer 2
Masse moléculaire calculée 615 aa, 66 kDa
Poids moléculaire observé 66 kDa
Numéro d’acquisition GenBankBC094787
Symbole du gène HIC2
Identification du gène (NCBI) 23119
Conjugaison Non conjugué
Forme Liquide
Méthode de purification Purification par affinité contre l'antigène
Tampon de stockage PBS only
Conditions de stockageStore at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

HIC2 (hypermethylated in cancer 2) is a transcription factor related to the tumour suppressor HIC1, required for normal cardiac development and lost in distal variants of 22q11 Deletion Syndrome (PMID: 29061339). HIC2 is also a POK family protein, and the amino acid sequence of its BTB/POZ and zinc-finger domains are similar to those of HIC1(PMID: 31127867). Studies have shown that HIC2 plays a role in suppressing fetal genes for normal development of the heart and circulatory system, in embryogenesis (PMID: 24748541).

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