Anticorps Polyclonal de lapin anti-HOPX

• Phare
• Validé par KD/KO

HOPX Polyclonal Antibody for WB, IHC, Indirect ELISA

Hôte / Isotype

Lapin / IgG

Réactivité testée

Humain, rat, souris

Applications

WB, IHC, Indirect ELISA

Conjugaison

Non conjugué

N° de cat : 11419-1-PBS

Synonymes

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Galerie de données de validation

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  WB analysis using 11419-1-AP (same clone as 11419-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 11419-1-AP (HOPX antibody) at dilution of 1:1500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 11419-1-PBS in a different storage buffer formulation.

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  WB analysis of mouse lung using 11419-1-AP (same clone as 11419-1-PBS)

  mouse lung tissue were subjected to SDS PAGE followed by western blot with 11419-1-AP (HOPX antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 11419-1-PBS in a different storage buffer formulation.

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  IHC staining of human placenta using 11419-1-AP (same clone as 11419-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human placenta tissue slide using 11419-1-AP (HOPX antibody) at dilution of 1:1000 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 11419-1-PBS in a different storage buffer formulation.

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  IHC staining of human placenta using 11419-1-AP (same clone as 11419-1-PBS)

  Immunohistochemical analysis of paraffin-embedded human placenta tissue slide using 11419-1-AP (HOPX antibody) at dilution of 1:1000 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 11419-1-PBS in a different storage buffer formulation.

• 

  IHC staining of mouse lung using 11419-1-AP (same clone as 11419-1-PBS)

  Immunohistochemical analysis of paraffin-embedded mouse lung tissue slide using 11419-1-AP (HOPX antibody) at dilution of 1:4000 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 11419-1-PBS in a different storage buffer formulation.

• 

  IHC staining of mouse lung using 11419-1-AP (same clone as 11419-1-PBS)

  Immunohistochemical analysis of paraffin-embedded mouse lung tissue slide using 11419-1-AP (HOPX antibody) at dilution of 1:4000 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 11419-1-PBS in a different storage buffer formulation.

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Informations sur le produit

11419-1-PBS cible HOPX dans les applications de WB, IHC, Indirect ELISA et montre une réactivité avec des échantillons Humain, rat, souris

• Réactivité: Humain, rat, souris
• Hôte / Isotype: Lapin / IgG
• Clonalité: Polyclonal
• Type: Anticorps
• Immunogène: HOPX Protéine recombinante Ag1979
• Nom complet: HOP homeobox
• Masse moléculaire calculée: 73 aa, 8 kDa
• Poids moléculaire observé: 8-12 kDa
• Numéro d’acquisition GenBank: BC014225
• Symbole du gène: HOPX
• Identification du gène (NCBI): 84525
• Conjugaison: Non conjugué
• Forme: Liquide
• Méthode de purification: Purification par affinité contre l'antigène
• Tampon de stockage: PBS only
• Conditions de stockage: Store at -80°C. 20ul contiennent 0,1% de BSA.

Informations générales

HOPX (Homeodomain-only protein) gene has various synonyms including HOD, HOP, OB1, LAGY and NECC1. The protein encoded by this gene is an unusual homeodomain protein that lacks certain conserved residues required for DNA binding. HOPX has diverse effects on cardiac growth. Manipulation of Hopx function in murine models is associated with cardiac hypertrophy, dilation and fibrosis. HOPX protein acts as an antagonist to the serum response factor (SRF), which regulates the opposing processes of cell proliferation and differentiation. Overexpression of HOPX causes cardiac hypertrophy. HOPX protein can inhibit SRF-dependent transcriptional activation by recruiting histone deacetylase (HDAC) activity.

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